Clinical features of perineuritis

Eric J. Sorenson, Anders A.F. Sima, Mila Blaivas, Kevin Sawchuk, John J. Wald

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We report 13 patients with pathologically confirmed perineuritis. Seven patients had diabetes mellitus, 5 had nutritional abnormalities, 2 had associated rheumatological illnesses, 2 had sepsis with multiorgan failure, and 1 had a history of malignancy. Electrophysiologic testing demonstrated mononeuritis multiplex in 7, demyelinating neuropathy in 4, distal sensory and motor neuropathy in 1, and polyradiculoneuropathy in 1. Twelve patients received immunomodulating therapy with variable responses. We conclude that perineuritis is associated with a number of different systemic conditions and several clinical patterns of peripheral neuropathy. Response to immunomodulation is variable. The most frequent association is with diabetes mellitus, a previously unrecognized association.

Original languageEnglish (US)
Pages (from-to)1153-1157
Number of pages5
JournalMuscle and Nerve
Volume20
Issue number9
DOIs
StatePublished - 1997

Keywords

  • Diabetes mellitus
  • Electrophysiology
  • Perineuritis
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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