Clinical features and outcomes of takotsubo (stress) cardiomyopathy

Christian Templin, Jelena R. Ghadri, Johanna Diekmann, L. Christian Napp, Dana R. Bataiosu, Milosz Jaguszewski, Victoria L. Cammann, Annahita Sarcon, Verena Geyer, Catharina A. Neumann, Burkhardt Seifert, Jens Hellermann, Moritz Schwyzer, Katharina Eisenhardt, Josef Jenewein, Jennifer Franke, Hugo A. Katus, Christof Burgdorf, Heribert Schunkert, Christian Moeller & 47 others Holger Thiele, Johann Bauersachs, Carsten Tschöpe, Heinz Peter Schultheiss, Charles A. Laney, Lawrence Rajan, Guido Michels, Roman Pfister, Christian Ukena, Michael Böhm, Raimund Erbel, Alessandro Cuneo, Karl Heinz Kuck, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Wolfgang Koenig, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Florim Cuculi, Adrian Banning, Thomas A. Fischer, Tuija Vasankari, K. E Juhani Airaksinen, Marcin Fijalkowski, Andrzej Rynkiewicz, Maciej Pawlak, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Wolfgang M. Franz, Klaus Empen, Stephan B. Felix, Clément Delmas, Olivier Lairez, Paul Erne, Jeroen J. Bax, Ian Ford, Frank Ruschitzka, Abhiram Prasad, Thomas F. Lüscher

Research output: Contribution to journalArticle

627 Citations (Scopus)

Abstract

Background: The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. Methods: The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. Results: Of 1750 patients with takotsubo cardiomyopathy, 89.8% were women (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of patients had no evident trigger. Among patients with takotsubo cardiomyopathy, as compared with an acute coronary syndrome, rates of neurologic or psychiatric disorders were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7±11.2% vs. 51.5±12.3%) (P

Original languageEnglish (US)
Pages (from-to)929-938
Number of pages10
JournalNew England Journal of Medicine
Volume373
Issue number10
DOIs
StatePublished - Sep 3 2015

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Takotsubo Cardiomyopathy
Acute Coronary Syndrome
Natural History
Stroke Volume
Nervous System
Psychiatry
Registries

ASJC Scopus subject areas

  • Medicine(all)

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Templin, C., Ghadri, J. R., Diekmann, J., Napp, L. C., Bataiosu, D. R., Jaguszewski, M., ... Lüscher, T. F. (2015). Clinical features and outcomes of takotsubo (stress) cardiomyopathy. New England Journal of Medicine, 373(10), 929-938. https://doi.org/10.1056/NEJMoa1406761

Clinical features and outcomes of takotsubo (stress) cardiomyopathy. / Templin, Christian; Ghadri, Jelena R.; Diekmann, Johanna; Napp, L. Christian; Bataiosu, Dana R.; Jaguszewski, Milosz; Cammann, Victoria L.; Sarcon, Annahita; Geyer, Verena; Neumann, Catharina A.; Seifert, Burkhardt; Hellermann, Jens; Schwyzer, Moritz; Eisenhardt, Katharina; Jenewein, Josef; Franke, Jennifer; Katus, Hugo A.; Burgdorf, Christof; Schunkert, Heribert; Moeller, Christian; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Schultheiss, Heinz Peter; Laney, Charles A.; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Ukena, Christian; Böhm, Michael; Erbel, Raimund; Cuneo, Alessandro; Kuck, Karl Heinz; Jacobshagen, Claudius; Hasenfuss, Gerd; Karakas, Mahir; Koenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M.; Braun-Dullaeus, Ruediger C.; Cuculi, Florim; Banning, Adrian; Fischer, Thomas A.; Vasankari, Tuija; Airaksinen, K. E Juhani; Fijalkowski, Marcin; Rynkiewicz, Andrzej; Pawlak, Maciej; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Franz, Wolfgang M.; Empen, Klaus; Felix, Stephan B.; Delmas, Clément; Lairez, Olivier; Erne, Paul; Bax, Jeroen J.; Ford, Ian; Ruschitzka, Frank; Prasad, Abhiram; Lüscher, Thomas F.

In: New England Journal of Medicine, Vol. 373, No. 10, 03.09.2015, p. 929-938.

Research output: Contribution to journalArticle

Templin, C, Ghadri, JR, Diekmann, J, Napp, LC, Bataiosu, DR, Jaguszewski, M, Cammann, VL, Sarcon, A, Geyer, V, Neumann, CA, Seifert, B, Hellermann, J, Schwyzer, M, Eisenhardt, K, Jenewein, J, Franke, J, Katus, HA, Burgdorf, C, Schunkert, H, Moeller, C, Thiele, H, Bauersachs, J, Tschöpe, C, Schultheiss, HP, Laney, CA, Rajan, L, Michels, G, Pfister, R, Ukena, C, Böhm, M, Erbel, R, Cuneo, A, Kuck, KH, Jacobshagen, C, Hasenfuss, G, Karakas, M, Koenig, W, Rottbauer, W, Said, SM, Braun-Dullaeus, RC, Cuculi, F, Banning, A, Fischer, TA, Vasankari, T, Airaksinen, KEJ, Fijalkowski, M, Rynkiewicz, A, Pawlak, M, Opolski, G, Dworakowski, R, MacCarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Crea, F, Dichtl, W, Franz, WM, Empen, K, Felix, SB, Delmas, C, Lairez, O, Erne, P, Bax, JJ, Ford, I, Ruschitzka, F, Prasad, A & Lüscher, TF 2015, 'Clinical features and outcomes of takotsubo (stress) cardiomyopathy', New England Journal of Medicine, vol. 373, no. 10, pp. 929-938. https://doi.org/10.1056/NEJMoa1406761
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. New England Journal of Medicine. 2015 Sep 3;373(10):929-938. https://doi.org/10.1056/NEJMoa1406761
Templin, Christian ; Ghadri, Jelena R. ; Diekmann, Johanna ; Napp, L. Christian ; Bataiosu, Dana R. ; Jaguszewski, Milosz ; Cammann, Victoria L. ; Sarcon, Annahita ; Geyer, Verena ; Neumann, Catharina A. ; Seifert, Burkhardt ; Hellermann, Jens ; Schwyzer, Moritz ; Eisenhardt, Katharina ; Jenewein, Josef ; Franke, Jennifer ; Katus, Hugo A. ; Burgdorf, Christof ; Schunkert, Heribert ; Moeller, Christian ; Thiele, Holger ; Bauersachs, Johann ; Tschöpe, Carsten ; Schultheiss, Heinz Peter ; Laney, Charles A. ; Rajan, Lawrence ; Michels, Guido ; Pfister, Roman ; Ukena, Christian ; Böhm, Michael ; Erbel, Raimund ; Cuneo, Alessandro ; Kuck, Karl Heinz ; Jacobshagen, Claudius ; Hasenfuss, Gerd ; Karakas, Mahir ; Koenig, Wolfgang ; Rottbauer, Wolfgang ; Said, Samir M. ; Braun-Dullaeus, Ruediger C. ; Cuculi, Florim ; Banning, Adrian ; Fischer, Thomas A. ; Vasankari, Tuija ; Airaksinen, K. E Juhani ; Fijalkowski, Marcin ; Rynkiewicz, Andrzej ; Pawlak, Maciej ; Opolski, Grzegorz ; Dworakowski, Rafal ; MacCarthy, Philip ; Kaiser, Christoph ; Osswald, Stefan ; Galiuto, Leonarda ; Crea, Filippo ; Dichtl, Wolfgang ; Franz, Wolfgang M. ; Empen, Klaus ; Felix, Stephan B. ; Delmas, Clément ; Lairez, Olivier ; Erne, Paul ; Bax, Jeroen J. ; Ford, Ian ; Ruschitzka, Frank ; Prasad, Abhiram ; Lüscher, Thomas F. / Clinical features and outcomes of takotsubo (stress) cardiomyopathy. In: New England Journal of Medicine. 2015 ; Vol. 373, No. 10. pp. 929-938.
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AU - Ghadri, Jelena R.

AU - Diekmann, Johanna

AU - Napp, L. Christian

AU - Bataiosu, Dana R.

AU - Jaguszewski, Milosz

AU - Cammann, Victoria L.

AU - Sarcon, Annahita

AU - Geyer, Verena

AU - Neumann, Catharina A.

AU - Seifert, Burkhardt

AU - Hellermann, Jens

AU - Schwyzer, Moritz

AU - Eisenhardt, Katharina

AU - Jenewein, Josef

AU - Franke, Jennifer

AU - Katus, Hugo A.

AU - Burgdorf, Christof

AU - Schunkert, Heribert

AU - Moeller, Christian

AU - Thiele, Holger

AU - Bauersachs, Johann

AU - Tschöpe, Carsten

AU - Schultheiss, Heinz Peter

AU - Laney, Charles A.

AU - Rajan, Lawrence

AU - Michels, Guido

AU - Pfister, Roman

AU - Ukena, Christian

AU - Böhm, Michael

AU - Erbel, Raimund

AU - Cuneo, Alessandro

AU - Kuck, Karl Heinz

AU - Jacobshagen, Claudius

AU - Hasenfuss, Gerd

AU - Karakas, Mahir

AU - Koenig, Wolfgang

AU - Rottbauer, Wolfgang

AU - Said, Samir M.

AU - Braun-Dullaeus, Ruediger C.

AU - Cuculi, Florim

AU - Banning, Adrian

AU - Fischer, Thomas A.

AU - Vasankari, Tuija

AU - Airaksinen, K. E Juhani

AU - Fijalkowski, Marcin

AU - Rynkiewicz, Andrzej

AU - Pawlak, Maciej

AU - Opolski, Grzegorz

AU - Dworakowski, Rafal

AU - MacCarthy, Philip

AU - Kaiser, Christoph

AU - Osswald, Stefan

AU - Galiuto, Leonarda

AU - Crea, Filippo

AU - Dichtl, Wolfgang

AU - Franz, Wolfgang M.

AU - Empen, Klaus

AU - Felix, Stephan B.

AU - Delmas, Clément

AU - Lairez, Olivier

AU - Erne, Paul

AU - Bax, Jeroen J.

AU - Ford, Ian

AU - Ruschitzka, Frank

AU - Prasad, Abhiram

AU - Lüscher, Thomas F.

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DO - 10.1056/NEJMoa1406761

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