TY - JOUR
T1 - Clinical epidemiology of primary biliary cirrhosis
T2 - Incidence, prevalence, and impact of therapy
AU - Lazaridis, Konstantinos N.
AU - Talwalkar, Jayant A.
PY - 2007/5
Y1 - 2007/5
N2 - Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. It is typically characterized by a trio of criteria including cholestatic liver biochemistry tests for at least 6 month's duration, the presence of a positive serum antimitochondrial antibody, and histologic findings from liver biopsy that are compatible or diagnostic with PBC. Although no unifying mechanism of action has been described to explain the pathogenesis of PBC to date, the natural history of this condition is greatly influenced by several known and unknown risk factors. In turn, a number of publications have focused on describing the burden of disease and prognosis in patients with PBC, This review article will summarize the descriptive epidemiology of PBC including new insights on risk factors, prognosis, and the effect of medical therapy in contemporary patients.
AB - Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of unknown etiology. It is typically characterized by a trio of criteria including cholestatic liver biochemistry tests for at least 6 month's duration, the presence of a positive serum antimitochondrial antibody, and histologic findings from liver biopsy that are compatible or diagnostic with PBC. Although no unifying mechanism of action has been described to explain the pathogenesis of PBC to date, the natural history of this condition is greatly influenced by several known and unknown risk factors. In turn, a number of publications have focused on describing the burden of disease and prognosis in patients with PBC, This review article will summarize the descriptive epidemiology of PBC including new insights on risk factors, prognosis, and the effect of medical therapy in contemporary patients.
KW - Biliary cirrhosis
KW - Epidemiology
KW - Natural history
UR - http://www.scopus.com/inward/record.url?scp=34247401795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247401795&partnerID=8YFLogxK
U2 - 10.1097/01.mcg.0000225653.07932.8f
DO - 10.1097/01.mcg.0000225653.07932.8f
M3 - Review article
C2 - 17450033
AN - SCOPUS:34247401795
SN - 0192-0790
VL - 41
SP - 494
EP - 500
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - 5
ER -