Clinical, diagnostic, genetic and management issues in dementia with Lewy bodies

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

DLB (dementia with Lewy bodies) is a syndrome associated with underlying LBD (Lewy body disease), with manifestations in the cognitive, neuropsychiatric, motor, sleep and autonomic domains. The variable symptomatology and complex array of neuronal involvement and neurotransmitter deficiencies make the diagnosis and management of patients with DLB challenging. The genetic underpinnings of DLB have only recently begun to unfold. In this review, the clinical features, diagnostic criteria, genetics and treatment issues relating to DLB will be discussed, in which a comprehensive approach to the diagnosis and management is emphasized.

Original languageEnglish (US)
Pages (from-to)343-354
Number of pages12
JournalClinical Science
Volume109
Issue number4
DOIs
StatePublished - Oct 1 2005

Keywords

  • Dementia with Lewy bodies (DLB)
  • Genetic basis
  • Lewy body disease
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine(all)

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