Clinical diagnostic criteria for dementia associated with Parkinson's disease

Murat Emre, Dag Aarsland, Richard Brown, David J. Burn, Charles Duyckaerts, Yoshikino Mizuno, Gerald Anthony Broe, Jeffrey Cummings, Dennis W. Dickson, Serge Gauthier, Jennifer Goldman, Christopher Goetz, Arnos Korczyn, Andrew Lees, Richard Levy, Irene Litvan, Ian McKeith, Warren Olanow, Werner Poewe, Niall QuinnChristina Sampaio, Eduardo Tolosa, Bruno Dubois

Research output: Contribution to journalReview article

1529 Scopus citations

Abstract

Dementia has been increasingly more recognized to be a common feature in patients with Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of dementia associated with PD (PD-D), however, have been lacking. A Task Force, organized by the Movement Disorder Study, was charged with the development of clinical diagnostic criteria for PD-D. The Task Force members were assigned to sub-committees and performed a systematic review of the literature, based on pre-defined selection criteria, in order to identify the epidemiological, clinical, auxiliary, and pathological features of PD-D. Clinical diagnostic criteria were then developed based on these findings and group consensus. The incidence of dementia in PD is increased up to six times, point-prevelance is close to 30%, older age and akinetic-rigid form are associated with higher risk. PD-D is characterized by impairment in attention, memory, executive and visuo-spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent. There are no specific ancillary investigations for the diagnosis; the main pathological correlate is Lewy body-type degeneration in cerebral cortex and limbic structures. Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed.

Original languageEnglish (US)
Pages (from-to)1689-1707
Number of pages19
JournalMovement Disorders
Volume22
Issue number12
DOIs
StatePublished - Sep 15 2007
Externally publishedYes

Keywords

  • Dementia
  • Diagnosis
  • Diagnostic criteria
  • Parkinson's disease
  • Parkinson's disease dementia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., Goldman, J., Goetz, C., Korczyn, A., Lees, A., Levy, R., Litvan, I., McKeith, I., Olanow, W., Poewe, W., ... Dubois, B. (2007). Clinical diagnostic criteria for dementia associated with Parkinson's disease. Movement Disorders, 22(12), 1689-1707. https://doi.org/10.1002/mds.21507