Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

Pedro J. Caraballo; Mark Parkulo; David Blair; Michelle Elliott; Cloann Schultz; Joseph Sutton; Padma Rao; Jamie Bruflat; Robert Bleimeyer; John Crooks; Donald Gabrielson; Wayne Nicholson; Carolyn Rohrer Vitek; Kelly Wix; Suzette J. Bielinski; Jyotishman Pathak; Iftikhar Kullo

doi:10.3233/978-1-61499-564-7-946

Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

Pedro J. Caraballo, Mark Parkulo, David Blair, Michelle Elliott, Cloann Schultz, Joseph Sutton, Padma Rao, Jamie Bruflat, Robert Bleimeyer, John Crooks, Donald Gabrielson, Wayne Nicholson, Carolyn Rohrer Vitek, Kelly Wix, Suzette J. Bielinski, Jyotishman Pathak, Iftikhar Kullo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use of clinical decision support has the potential to prevent adverse effects from those drugs metabolized by this enzyme. Our initial findings after implementation of clinical decision support alerts integrated in the electronic health records suggest high feasibility, but also identify important challenges.

Original language	English (US)
Title of host publication	MEDINFO 2015
Subtitle of host publication	eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics
Editors	Andrew Georgiou, Indra Neil Sarkar, Paulo Mazzoncini de Azevedo Marques
Publisher	IOS Press
Pages	946
Number of pages	1
ISBN (Electronic)	9781614995630
DOIs	https://doi.org/10.3233/978-1-61499-564-7-946
State	Published - 2015
Event	15th World Congress on Health and Biomedical Informatics, MEDINFO 2015 - Sao Paulo, Brazil Duration: Aug 19 2015 → Aug 23 2015

Publication series

Name	Studies in Health Technology and Informatics
Volume	216
ISSN (Print)	0926-9630
ISSN (Electronic)	1879-8365

Other

Other	15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
Country/Territory	Brazil
City	Sao Paulo
Period	8/19/15 → 8/23/15

Keywords

Clinical Decision Support Systems
Cytochrome P-450 CYP2D6
Electronic Health Records
Pharmacogenomics

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Health Information Management

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10.3233/978-1-61499-564-7-946

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Caraballo, P. J., Parkulo, M., Blair, D., Elliott, M., Schultz, C., Sutton, J., Rao, P., Bruflat, J., Bleimeyer, R., Crooks, J., Gabrielson, D., Nicholson, W., Rohrer Vitek, C., Wix, K., Bielinski, S. J., Pathak, J., & Kullo, I. (2015). Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. In A. Georgiou, I. N. Sarkar, & P. M. de Azevedo Marques (Eds.), MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics (pp. 946). (Studies in Health Technology and Informatics; Vol. 216). IOS Press. https://doi.org/10.3233/978-1-61499-564-7-946

Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. / Caraballo, Pedro J.; Parkulo, Mark; Blair, David et al.
MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics. ed. / Andrew Georgiou; Indra Neil Sarkar; Paulo Mazzoncini de Azevedo Marques. IOS Press, 2015. p. 946 (Studies in Health Technology and Informatics; Vol. 216).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Caraballo, PJ, Parkulo, M, Blair, D, Elliott, M, Schultz, C, Sutton, J, Rao, P, Bruflat, J, Bleimeyer, R, Crooks, J, Gabrielson, D, Nicholson, W, Rohrer Vitek, C, Wix, K, Bielinski, SJ, Pathak, J & Kullo, I 2015, Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. in A Georgiou, IN Sarkar & PM de Azevedo Marques (eds), MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics. Studies in Health Technology and Informatics, vol. 216, IOS Press, pp. 946, 15th World Congress on Health and Biomedical Informatics, MEDINFO 2015, Sao Paulo, Brazil, 8/19/15. https://doi.org/10.3233/978-1-61499-564-7-946

Caraballo PJ, Parkulo M, Blair D, Elliott M, Schultz C, Sutton J et al. Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. In Georgiou A, Sarkar IN, de Azevedo Marques PM, editors, MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics. IOS Press. 2015. p. 946. (Studies in Health Technology and Informatics). doi: 10.3233/978-1-61499-564-7-946

Caraballo, Pedro J. ; Parkulo, Mark ; Blair, David et al. / Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. MEDINFO 2015: eHealth-Enabled Health - Proceedings of the 15th World Congress on Health and Biomedical Informatics. editor / Andrew Georgiou ; Indra Neil Sarkar ; Paulo Mazzoncini de Azevedo Marques. IOS Press, 2015. pp. 946 (Studies in Health Technology and Informatics).

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Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

Abstract

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Keywords

ASJC Scopus subject areas

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