Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction

Pedro Caraballo, Mark Parkulo, David Blair, Michelle Elliott, Cloann Schultz, Joseph Sutton, Padma Rao, Jamie Bruflat, Robert Bleimeyer, John Crooks, Donald Gabrielson, Wayne Nicholson, Carolyn Rohrer Vitek, Kelly Wix, Suzette J Bielinski, Jyotishman Pathak, Iftikhar Jan Kullo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use of clinical decision support has the potential to prevent adverse effects from those drugs metabolized by this enzyme. Our initial findings after implementation of clinical decision support alerts integrated in the electronic health records suggest high feasibility, but also identify important challenges.

Original languageEnglish (US)
Title of host publicationStudies in Health Technology and Informatics
PublisherIOS Press
Pages946
Number of pages1
Volume216
ISBN (Print)9781614995630
DOIs
StatePublished - 2015
Event15th World Congress on Health and Biomedical Informatics, MEDINFO 2015 - Sao Paulo, Brazil
Duration: Aug 19 2015Aug 23 2015

Publication series

NameStudies in Health Technology and Informatics
Volume216
ISSN (Print)09269630
ISSN (Electronic)18798365

Other

Other15th World Congress on Health and Biomedical Informatics, MEDINFO 2015
CountryBrazil
CitySao Paulo
Period8/19/158/23/15

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Keywords

  • Clinical Decision Support Systems
  • Cytochrome P-450 CYP2D6
  • Electronic Health Records
  • Pharmacogenomics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

Cite this

Caraballo, P., Parkulo, M., Blair, D., Elliott, M., Schultz, C., Sutton, J., Rao, P., Bruflat, J., Bleimeyer, R., Crooks, J., Gabrielson, D., Nicholson, W., Rohrer Vitek, C., Wix, K., Bielinski, S. J., Pathak, J., & Kullo, I. J. (2015). Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction. In Studies in Health Technology and Informatics (Vol. 216, pp. 946). (Studies in Health Technology and Informatics; Vol. 216). IOS Press. https://doi.org/10.3233/978-1-61499-564-7-946