Clinical course of patients with incidental finding of 20q- in the bone marrow without a morphologic evidence of myeloid neoplasm

Majd D. Jawad, Min Shi, Jennifer Oliveira, James Hoyer, C. Christopher Hook, Ronald S. Go

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6 Citations (Scopus)

Abstract

Deletion of the long arm of chromosome 20 (20q-) is a frequent finding in bone marrow karyotypes, mainly associated with myeloid neoplasms (MNs). Its clinical significance in the setting of normal bone marrow morphology is unclear. We described the clinical characteristics, cytogenetic findings, and outcome of 102 such patients seen at our institution from 2000-2014. Their median age was 66 years. The indication for bone marrow biopsy was either unexplained cytopenias (48%) or hematologic cancer staging/reevaluation (52%). In 88 (86%) patients, 20q- was an isolated finding. Thirty-nine (38%) patients previously received chemotherapy and 88 (86%) had cytopenias at the time of 20q- finding. After a median of 35 months, 12 (13%) patients developed MNs: 10 myelodysplastic syndromes, one acute myeloid leukemia and one myeloproliferative neoplasm. None of 14 patients with normal blood counts, but 7 of 35 (20%) with mild cytopenias, and 5 of 53 (9%) with moderate/severe cytopenias developed MNs. We did not find an association between the number of metaphases with 20q- and the development of MN. The incidental finding of 20q- in the bone marrow generally does not portend an early stage MN. Particularly, those without cytopenias at the time of diagnosis may have a good prognosis.

Original languageEnglish (US)
JournalAmerican Journal of Hematology
DOIs
StateAccepted/In press - 2016

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Incidental Findings
Bone Marrow
Neoplasms
Chromosomes, Human, Pair 20
Neoplasm Staging
Myelodysplastic Syndromes
Metaphase
Karyotype
Acute Myeloid Leukemia
Cytogenetics
Biopsy
Drug Therapy

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Clinical course of patients with incidental finding of 20q- in the bone marrow without a morphologic evidence of myeloid neoplasm",
abstract = "Deletion of the long arm of chromosome 20 (20q-) is a frequent finding in bone marrow karyotypes, mainly associated with myeloid neoplasms (MNs). Its clinical significance in the setting of normal bone marrow morphology is unclear. We described the clinical characteristics, cytogenetic findings, and outcome of 102 such patients seen at our institution from 2000-2014. Their median age was 66 years. The indication for bone marrow biopsy was either unexplained cytopenias (48{\%}) or hematologic cancer staging/reevaluation (52{\%}). In 88 (86{\%}) patients, 20q- was an isolated finding. Thirty-nine (38{\%}) patients previously received chemotherapy and 88 (86{\%}) had cytopenias at the time of 20q- finding. After a median of 35 months, 12 (13{\%}) patients developed MNs: 10 myelodysplastic syndromes, one acute myeloid leukemia and one myeloproliferative neoplasm. None of 14 patients with normal blood counts, but 7 of 35 (20{\%}) with mild cytopenias, and 5 of 53 (9{\%}) with moderate/severe cytopenias developed MNs. We did not find an association between the number of metaphases with 20q- and the development of MN. The incidental finding of 20q- in the bone marrow generally does not portend an early stage MN. Particularly, those without cytopenias at the time of diagnosis may have a good prognosis.",
author = "Jawad, {Majd D.} and Min Shi and Jennifer Oliveira and James Hoyer and {Christopher Hook}, C. and Go, {Ronald S.}",
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AU - Jawad, Majd D.

AU - Shi, Min

AU - Oliveira, Jennifer

AU - Hoyer, James

AU - Christopher Hook, C.

AU - Go, Ronald S.

PY - 2016

Y1 - 2016

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