Clinical correlates of submicroscopic deletions involving the ABL-BCR translocation region in chronic myeloid leukemia

Yinlee Yoong, Todd J. VanDeWalker, Richard O. Carlson, Gordon W. Dewald, Ayalew Tefferi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Recent reports indicate a prognostically detrimental effect of submicroscopic abl-bcr deletions associated with the break and fusion points of the derivative chromosome 9 [der(9)] in chronic myeloid leukemia (CML). In a retrospective cohort of 92 patients with CML, the incidence of an atypical D-FISH pattern, that is consistent with a der(9) deletion was 20%. Complete clinical information was available in 82 patients and revealed no significant differences between 18 deleted and 64 non-deleted cases in platelet count, circulating blast percentage, spleen size, or karyotype profile at presentation. However, der(9)-deleted patients presented with significantly lower hemoglobin levels and higher leukocyte counts. At a median follow-up of 31 months, the incidence of disease transformation, drug therapy response, and survival were similar between the two groups. These results are contrary to previous reports that suggested inferior survival as well as poor response to alpha interferon therapy in CML patients carrying der(9) deletions.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalEuropean Journal of Haematology
Volume74
Issue number2
DOIs
StatePublished - Feb 2005

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Chromosomes, Human, Pair 9
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chromosome Deletion
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Survival
Incidence
Platelet Count
Karyotype
Leukocyte Count
Interferon-alpha
Hemoglobins
Spleen
Drug Therapy
Therapeutics

Keywords

  • abl/bcr
  • Chronic
  • Deletion
  • FISH
  • Leukemia
  • Myeloid

ASJC Scopus subject areas

  • Hematology

Cite this

Clinical correlates of submicroscopic deletions involving the ABL-BCR translocation region in chronic myeloid leukemia. / Yoong, Yinlee; VanDeWalker, Todd J.; Carlson, Richard O.; Dewald, Gordon W.; Tefferi, Ayalew.

In: European Journal of Haematology, Vol. 74, No. 2, 02.2005, p. 124-127.

Research output: Contribution to journalArticle

Yoong, Yinlee ; VanDeWalker, Todd J. ; Carlson, Richard O. ; Dewald, Gordon W. ; Tefferi, Ayalew. / Clinical correlates of submicroscopic deletions involving the ABL-BCR translocation region in chronic myeloid leukemia. In: European Journal of Haematology. 2005 ; Vol. 74, No. 2. pp. 124-127.
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