TY - JOUR
T1 - Clinical characteristics of a group of adults with nodular lymphoid hyperplasia
T2 - A single center experience
AU - Rubio-Tapia, Alberta
AU - Hernández-Calleros, Jorge
AU - Trinidad-Hernández, Sagrario
AU - Uscanga, Luis
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2006/3/28
Y1 - 2006/3/28
N2 - Aim: To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia (NLH). Methods: Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. Results: Small-bowel NLH was diagnosed in 18 cases. The female : male ratio was 2: 1. The most frequent symptoms were diarrhea (72%), involuntary weight loss (72%) and abdominal pain (61%). Nine patients (50%) had immunodeficiency. Small-bowel bacterial overgrowth was found in three (17%) cases. At small-bowel NLH diagnosis, three (17%) had associated lymphoma: two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia lamblia infection was found in only one patient with hypogammaglobulinemia (Herman's syndrome). Conclusions: NLH is uncommon in adult patients. Associated d iseases are immunodeficiency and lymphoid tissue malignancies.
AB - Aim: To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia (NLH). Methods: Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. Results: Small-bowel NLH was diagnosed in 18 cases. The female : male ratio was 2: 1. The most frequent symptoms were diarrhea (72%), involuntary weight loss (72%) and abdominal pain (61%). Nine patients (50%) had immunodeficiency. Small-bowel bacterial overgrowth was found in three (17%) cases. At small-bowel NLH diagnosis, three (17%) had associated lymphoma: two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia lamblia infection was found in only one patient with hypogammaglobulinemia (Herman's syndrome). Conclusions: NLH is uncommon in adult patients. Associated d iseases are immunodeficiency and lymphoid tissue malignancies.
KW - Hypogamma-globulinemia
KW - Lymphoma
KW - Nodular lymphoid hyperplasia
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U2 - 10.3748/wjg.v12.i12.1945
DO - 10.3748/wjg.v12.i12.1945
M3 - Article
C2 - 16610004
AN - SCOPUS:33645994792
SN - 1007-9327
VL - 12
SP - 1945
EP - 1948
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 12
ER -