Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA

Bo Deng, Julian R Molina, Marie C. Aubry, Zhifu D Sun, Liang Wang, Bruce W. Eckloff, George Vasmatzis, Ming You, Eric D Wieben, Jin Jen, Dennis A Wigle, Ping Yang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs.Results: From the total of 1145 miRNAs, we obtained 16 and 17 miRNAs that showed positive and negative fold changes (FCs, tumors vs. normal tissues) in the top 1% differentially expressed miRNAs, respectively. We uncovered the target genes that were predicted by at least two prediction tools and overlapped by at least one-half of the top miRNAs, which yielded 44 genes (FC<-2) and 56 genes (FC>2), respectively. Higher expressions of CREB5, PTPRB and COL4A3 predicted favorable disease free survival (Hazard ratio: 0.03, 0.19 and 0.36; P value: 0.03, 0.03 and 0.08). Additionally, 79 mutated genes have been found in nine PCTs where TP53 was the only repeated mutation.Conclusion: We identified that the expressions of three genes have clinical implications in PCTs. The biological functions of these biomarkers warrant further studies.

Original languageEnglish (US)
Article number35
JournalCell and Bioscience
Volume4
Issue number1
DOIs
StatePublished - Jul 9 2014

Fingerprint

Carcinoid Tumor
Biomarkers
MicroRNAs
Tumors
Genes
Lung
Messenger RNA
Pathologic Processes
Disease-Free Survival
Neoplasms
Hazards
Tissue
Gene Expression
Mutation

Keywords

  • Carcinoid
  • miRNA
  • mRNA
  • Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA. / Deng, Bo; Molina, Julian R; Aubry, Marie C.; Sun, Zhifu D; Wang, Liang; Eckloff, Bruce W.; Vasmatzis, George; You, Ming; Wieben, Eric D; Jen, Jin; Wigle, Dennis A; Yang, Ping.

In: Cell and Bioscience, Vol. 4, No. 1, 35, 09.07.2014.

Research output: Contribution to journalArticle

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AU - Deng, Bo

AU - Molina, Julian R

AU - Aubry, Marie C.

AU - Sun, Zhifu D

AU - Wang, Liang

AU - Eckloff, Bruce W.

AU - Vasmatzis, George

AU - You, Ming

AU - Wieben, Eric D

AU - Jen, Jin

AU - Wigle, Dennis A

AU - Yang, Ping

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