TY - JOUR
T1 - Clinical aspects of antimicrobial resistance
AU - Virk, Abinash
AU - Steckelberg, James M.
PY - 2000
Y1 - 2000
N2 - Soon after penicillin was introduced into clinical use, an enzyme (penicillinase) that inactivated it was discovered. Since then, the variety of antimicrobial agents has increased substantially, along with a parallel increase in resistant pathogenic microorganisms. Resistance is now recognized against all available antimicrobial agents. Factors influencing the emergence of resistance include indiscriminate use of antibiotics, prolonged hospitalizations, increasing numbers of immunocompromised patients, and medical progress resulting in increased use of invasive procedures and devices. This article provides an update on clinical aspects of a few commonly found resistant microorganisms relevant to day-to-day clinical practice. A discussion of all resistant organisms is beyond the scope of this report. Both viral and mycobacterial resistance have been addressed in previous articles in this symposium.
AB - Soon after penicillin was introduced into clinical use, an enzyme (penicillinase) that inactivated it was discovered. Since then, the variety of antimicrobial agents has increased substantially, along with a parallel increase in resistant pathogenic microorganisms. Resistance is now recognized against all available antimicrobial agents. Factors influencing the emergence of resistance include indiscriminate use of antibiotics, prolonged hospitalizations, increasing numbers of immunocompromised patients, and medical progress resulting in increased use of invasive procedures and devices. This article provides an update on clinical aspects of a few commonly found resistant microorganisms relevant to day-to-day clinical practice. A discussion of all resistant organisms is beyond the scope of this report. Both viral and mycobacterial resistance have been addressed in previous articles in this symposium.
UR - http://www.scopus.com/inward/record.url?scp=0033953344&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033953344&partnerID=8YFLogxK
U2 - 10.4065/75.2.200
DO - 10.4065/75.2.200
M3 - Article
C2 - 10683663
AN - SCOPUS:0033953344
SN - 0025-6196
VL - 75
SP - 200
EP - 214
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 2
ER -