Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy

J. L D Atkinson, G. M. Miller, W. E. Krauss, W. R. Marsh, D. G. Piepgras, P. P. Atkinson, Robert D Jr. Brown, J. I. Lane

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Abstract

Objective: To assess presentation, imaging, treatment, and outcome of patients with myelopathy due to a dural arteriovenous fistula (DAVF). Patients and Methods: This retrospective review identified 94 patients with DAVF surgically treated at our institution between June 1985 and December 1999. The mean ages of the 75 men and 19 women were 62.6 years and 63.0 years, respectively (range, 31-83 years). Magnetic resonance imaging was performed in 87 patients, computed tomography-myelography was performed in 37 patients, and spinal angiography was performed in all patients. Initial examination findings were retrospectively adjusted to a modified Aminoff-Logue myelopathy scale. Results: Of the 94 patients, 47 presented with symptoms that worsened with erect posture or Valsalva maneuver. As myelopathy progressed, patients' symptoms increased, and 6 patients had paraplegia at presentation. The mean time from symptom onset to diagnosis was 23 months (range, 2-120 months). Magnetic resonance imaging confirmed the diagnosis in 86 patients; computed tomography-myelography was needed to confirm the fistula in 1 patient. Spinal angiography detected the fistula in all patients. Surgical obliteration of the DAVF was successful in 93 patients; in 1 patient surgery failed because the DAVF was not localized, but acrylic endovascular embolization was successful. No patient experienced permanent morbidity or mortality. Of the 94 patients, 93 improved postoperatively 1 or 2 levels based on a modified AminoffLogue scale. Older patients with severe long-term deficits had poor outcomes. Conclusions: The diagnosis of a DAVF seems to be delayed considerably because DAVF is not included in the differential diagnosis of myelopathy and because of clinicians' unfamiliarity with suggestive or revealing findings on diagnostic imaging. Neurodiagnostic imaging confirms the diagnosis, and spinal angiography localizes the fistula. Surgical intradural disconnection of the DAVF clinically reverses the pathophysiology. Additionally, surgical treatment is associated with low short-term morbidity, no permanent morbidity, and no mortality. If the diagnosis is made early and treatment initiated in such patients, they generally do well.

Original languageEnglish (US)
Pages (from-to)1120-1130
Number of pages11
JournalMayo Clinic Proceedings
Volume76
Issue number11
StatePublished - 2001

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Central Nervous System Vascular Malformations
Spinal Cord Diseases
Fistula
Angiography
Myelography
Morbidity
Tomography
Magnetic Resonance Imaging
Valsalva Maneuver

Keywords

  • AP = anteroposterior
  • CT = computed tomography
  • DAVF = dural arteriovenous fistula
  • MRI = magnetic resonance imaging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Atkinson, J. L. D., Miller, G. M., Krauss, W. E., Marsh, W. R., Piepgras, D. G., Atkinson, P. P., ... Lane, J. I. (2001). Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy. Mayo Clinic Proceedings, 76(11), 1120-1130.

Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy. / Atkinson, J. L D; Miller, G. M.; Krauss, W. E.; Marsh, W. R.; Piepgras, D. G.; Atkinson, P. P.; Brown, Robert D Jr.; Lane, J. I.

In: Mayo Clinic Proceedings, Vol. 76, No. 11, 2001, p. 1120-1130.

Research output: Contribution to journalArticle

Atkinson, JLD, Miller, GM, Krauss, WE, Marsh, WR, Piepgras, DG, Atkinson, PP, Brown, RDJ & Lane, JI 2001, 'Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy', Mayo Clinic Proceedings, vol. 76, no. 11, pp. 1120-1130.
Atkinson JLD, Miller GM, Krauss WE, Marsh WR, Piepgras DG, Atkinson PP et al. Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy. Mayo Clinic Proceedings. 2001;76(11):1120-1130.
Atkinson, J. L D ; Miller, G. M. ; Krauss, W. E. ; Marsh, W. R. ; Piepgras, D. G. ; Atkinson, P. P. ; Brown, Robert D Jr. ; Lane, J. I. / Clinical and radiographic features of dural arteriovenous fistula, a treatable cause of myelopathy. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 11. pp. 1120-1130.
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AU - Krauss, W. E.

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AU - Piepgras, D. G.

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AB - Objective: To assess presentation, imaging, treatment, and outcome of patients with myelopathy due to a dural arteriovenous fistula (DAVF). Patients and Methods: This retrospective review identified 94 patients with DAVF surgically treated at our institution between June 1985 and December 1999. The mean ages of the 75 men and 19 women were 62.6 years and 63.0 years, respectively (range, 31-83 years). Magnetic resonance imaging was performed in 87 patients, computed tomography-myelography was performed in 37 patients, and spinal angiography was performed in all patients. Initial examination findings were retrospectively adjusted to a modified Aminoff-Logue myelopathy scale. Results: Of the 94 patients, 47 presented with symptoms that worsened with erect posture or Valsalva maneuver. As myelopathy progressed, patients' symptoms increased, and 6 patients had paraplegia at presentation. The mean time from symptom onset to diagnosis was 23 months (range, 2-120 months). Magnetic resonance imaging confirmed the diagnosis in 86 patients; computed tomography-myelography was needed to confirm the fistula in 1 patient. Spinal angiography detected the fistula in all patients. Surgical obliteration of the DAVF was successful in 93 patients; in 1 patient surgery failed because the DAVF was not localized, but acrylic endovascular embolization was successful. No patient experienced permanent morbidity or mortality. Of the 94 patients, 93 improved postoperatively 1 or 2 levels based on a modified AminoffLogue scale. Older patients with severe long-term deficits had poor outcomes. Conclusions: The diagnosis of a DAVF seems to be delayed considerably because DAVF is not included in the differential diagnosis of myelopathy and because of clinicians' unfamiliarity with suggestive or revealing findings on diagnostic imaging. Neurodiagnostic imaging confirms the diagnosis, and spinal angiography localizes the fistula. Surgical intradural disconnection of the DAVF clinically reverses the pathophysiology. Additionally, surgical treatment is associated with low short-term morbidity, no permanent morbidity, and no mortality. If the diagnosis is made early and treatment initiated in such patients, they generally do well.

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KW - CT = computed tomography

KW - DAVF = dural arteriovenous fistula

KW - MRI = magnetic resonance imaging

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