Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Josa M. Frischer, Stephen D. Weigand, Yong Guo, Nilufer Kale, Joseph E. Parisi, Istvan Pirko, Jay Mandrekar, Stephan Bramow, Imke Metz, Wolfgang Brück, Hans Lassmann, Claudia F. Lucchinetti

Research output: Contribution to journalArticlepeer-review

216 Scopus citations


Objective An extensive analysis of white matter plaques in a large sample of multiple sclerosis (MS) autopsies provides insights into the dynamic nature of MS pathology. Methods One hundred twenty MS cases (1,220 tissue blocks) were included. Plaque types were classified according to demyelinating activity based on stringent criteria. Early active, late active, smoldering, inactive, and shadow plaques were distinguished. A total of 2,476 MS white matter plaques were identified. Plaque type distribution was analyzed in relation to clinical data. Results Active plaques were most often found in early disease, whereas at later stages, smoldering, inactive, and shadow plaques predominated. The presence of early active plaques rapidly declined with disease duration. Plaque type distribution differed significantly by clinical course. The majority of plaques in acute monophasic and relapsing-remitting MS (RRMS) were active. Among secondary progressive MS (SPMS) cases with attacks, all plaque types could be distinguished including active plaques, in contrast to SPMS without attacks, in which inactive plaques predominated. Smoldering plaques were frequently and almost exclusively found in progressive MS. At 47 years of age, an equilibrium was observed between active and inactive plaques, whereas smoldering plaques began to peak. Men displayed a higher proportion of smoldering plaques. Interpretation Disease duration, clinical course, age, and gender contribute to the dynamic nature of white matter MS pathology. Active MS plaques predominate in acute and early RRMS and are the likely substrate of clinical attacks. Progressive MS transitions to an accumulation of smoldering plaques characterized by microglial activation and slow expansion of pre-existing plaques. Whether current MS therapeutics impact this pathological driver of disease progression remains uncertain.

Original languageEnglish (US)
Pages (from-to)710-721
Number of pages12
JournalAnnals of neurology
Issue number5
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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