Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone

C. J. Gibbs, A. Joy, R. Heffner, M. Franko, M. Miyazaki, D. M. Asher, Joseph E Parisi, P. W. Brown, D. C. Gajdusek

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

This report describes the medical history of another such patient, a young man from Buffalo, and presents data on the clinical, pathological, and laboratory confirmation of Creutzfeldt-Jakob disease by isolation and identification of scrapie-associated fibrils with immunoelectron microscopy using rabbit antibodies to scrapie-associated fibrils, and by identification of the scrapie-associated fibril protein PrP27-30 with Western immunoblots using fresh-frozen brain taken at autopsy of the patient. Attempts to isolate scrapie-associated fibrils and the asscociated PrP27-30 protein from formalin-fixed brain tissues were unsuccessful.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalNew England Journal of Medicine
Volume313
Issue number12
StatePublished - 1985
Externally publishedYes

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PrP 27-30 Protein
Creutzfeldt-Jakob Syndrome
Human Growth Hormone
Immunoelectron Microscopy
Buffaloes
Brain
Formaldehyde
Autopsy
Western Blotting
History
Rabbits
Antibodies
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gibbs, C. J., Joy, A., Heffner, R., Franko, M., Miyazaki, M., Asher, D. M., ... Gajdusek, D. C. (1985). Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone. New England Journal of Medicine, 313(12), 734-738.

Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone. / Gibbs, C. J.; Joy, A.; Heffner, R.; Franko, M.; Miyazaki, M.; Asher, D. M.; Parisi, Joseph E; Brown, P. W.; Gajdusek, D. C.

In: New England Journal of Medicine, Vol. 313, No. 12, 1985, p. 734-738.

Research output: Contribution to journalArticle

Gibbs, CJ, Joy, A, Heffner, R, Franko, M, Miyazaki, M, Asher, DM, Parisi, JE, Brown, PW & Gajdusek, DC 1985, 'Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone', New England Journal of Medicine, vol. 313, no. 12, pp. 734-738.
Gibbs, C. J. ; Joy, A. ; Heffner, R. ; Franko, M. ; Miyazaki, M. ; Asher, D. M. ; Parisi, Joseph E ; Brown, P. W. ; Gajdusek, D. C. / Clinical and pathological features and laboratory confirmation of Creutzfeldt-Jakob disease in a recipient of pituitary-derived human growth hormone. In: New England Journal of Medicine. 1985 ; Vol. 313, No. 12. pp. 734-738.
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