Clinical and Pathological Features and Laboratory Confirmation of Creutzfeldt–Jakob Disease in a Recipient of Pituitary-Derived Human Growth Hormone

Clarence J. Gibbs, Anthony Joy, Reid Heffner, Maryellen Franko, Masayuki Miyazaki, David M. Asher, Joseph E. Parisi, Paul W. Brown, D. Carleton Gajdusek

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Abstract

A COMPANION paper in this issue1 reports on the apparent iatrogenic transmission of Creutzfeldt—Jakob disease to a young adult who had been a recipient of human pituitary growth hormone. This report describes the medical history of another such patient, a young man from Buffalo, and presents data on the clinical, pathological, and laboratory confirmation of Creutzfeldt—Jakob disease by isolation and identification of scrapie-associated fibrils with immunoelectron microscopy using rabbit antibodies to scrapie-associated fibrils, and by identification of the scrapie-associated fibril protein PrP27–30 with Western immunoblots using fresh-frozen brain taken at autopsy of the patient. Attempts to isolate scrapie-associated fibrils.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalNew England Journal of Medicine
Volume313
Issue number12
DOIs
StatePublished - Sep 19 1985

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ASJC Scopus subject areas

  • Medicine(all)

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Gibbs, C. J., Joy, A., Heffner, R., Franko, M., Miyazaki, M., Asher, D. M., Parisi, J. E., Brown, P. W., & Gajdusek, D. C. (1985). Clinical and Pathological Features and Laboratory Confirmation of Creutzfeldt–Jakob Disease in a Recipient of Pituitary-Derived Human Growth Hormone. New England Journal of Medicine, 313(12), 734-738. https://doi.org/10.1056/NEJM198509193131207