Clinical and operative characteristics of patients randomized to coronary artery bypass surgery in the Bypass Angioplasty Revascularization Investigation (BARI)

Hartzell V. Schaff, Allan D. Rosen, Richard J. Shemin, Yves Leclerc, Thomas H. Wareing, Frank V. Aguirre, George Sopko, Thomas J. VanderSalm, Floyd D. Loop, Investigators BARI Investigators

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34 Scopus citations

Abstract

The surgical cohort of the Bypass Angioplasty Revascularization Investigation (BARI) is the largest group of patients with multivessel coronary artery disease randomly assigned to surgical treatment. This report presents baseline and operative characteristics of the cohort and describes some aspects of the variability in surgical practice among the 14 primary clinical centers and 4 co-investigational sites participating in BARI. Preoperative clinical and angiographic data and intraoperative variables were reviewed in 892 patients who were randomly assigned to coronary artery bypass grafting (CABG) and underwent operation. Associations between patient/lesion variables and operative characteristics are described. Of patients assigned to CABG, 87% underwent an operation within 2 weeks of randomization, as recommended in the protocol. Mean age of the 892 patients was 61 years, and mean age of the 235 women was greater than that of men (64 years vs 60 years); 64% of the surgical patients were classified as having unstable angina during the 6 weeks prior to randomization. Coronary angiography demonstrated 3-vessel disease (50% diameter narrowing by caliper measurement) in 41% of patients, and disease of the left anterior descending coronary artery was present in 87% of patients. A mean of 3.1 coronary arteries per patient were bypassed, and 82% of patients received 1 (70%) or 2 (12%) internal thoracic artery grafts. Prevalence of internal thoracic grafts was lower in elderly patients (74% of patients ≥ 70 years), in women (72% vs 85% in men; p < 0.01), and in black participants (65%). There was significant center-to-center variation in duration of cardiopulmonary bypass and aortic cross-clamping, methods of intraoperative myocardial protection, and in graft usage. Surgical patients in BARI differ considerably from patients entered into previous randomized trials in that the operative methods and graft usage reflect contemporary practice of coronary artery surgery, although significant variations among institutions were observed.

Original languageEnglish (US)
Pages (from-to)C18-C26
JournalAmerican Journal of Cardiology
Volume75
Issue number9
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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