Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG

Ichiro Nakashima, K. Fujihara, I. Miyazawa, T. Misu, K. Narikawa, M. Nakamura, S. Watanabe, T. Takahashi, S. Nishiyama, Y. Shiga, S. Sato, Brian G Weinshenker, Y. Itoyama

Research output: Contribution to journalArticle

204 Scopus citations


This study investigates the relation between the serological status of NMO (neuromyelitis optica)-IgG and the clinical and MRI features in Japanese patients with multiple sclerosis. Serum NMO-IgG was tested in 35 Japanese patients diagnosed with multiple sclerosis, including 19 with the optic-spinal form of multiple sclerosis (OSMS), three with the spinal form of multiple sclerosis (SMS), and 13 with the conventional form of multiple sclerosis (CMS), which affects the brain. NMO-IgG was detected in 14 patients, 12 with OSMS and 2 with CMS. In these patients, longitudinally extensive (>3 vertebral segments) spinal cord lesions (93% v 57%) and permanent, complete blindness (no perception of light) in at least one eye (50% v 0%) were the noticeable features as compared with NMO-IgG-negative OSMS. The two patients having CMS with NMO-IgG had unusual brain lesions, but in other respects had features suggesting OSMS. NMO-IgG was detected in more than half the number of patients with OSMS and in some patients with CMS. This newly discovered serum autoantibody was markedly associated with longitudinally extensive spinal cord lesions and with complete blindness, suggesting severe optic-spinal disease.

Original languageEnglish (US)
Pages (from-to)1073-1075
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number9
StatePublished - Sep 2006


ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Nakashima, I., Fujihara, K., Miyazawa, I., Misu, T., Narikawa, K., Nakamura, M., Watanabe, S., Takahashi, T., Nishiyama, S., Shiga, Y., Sato, S., Weinshenker, B. G., & Itoyama, Y. (2006). Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMO-IgG. Journal of Neurology, Neurosurgery and Psychiatry, 77(9), 1073-1075.