Abstract
Background: Granuloma annulare (GA) is a granulomatous skin eruption rarely associated with cancer. We report seven cases of paraneoplastic GA in association with solid organ malignancy. Objective: To compare the clinical and histopathological features of paraneoplastic GA to case-matched controls of classic GA. Methods: Retrospective chart and histopathological review of 7 individuals and 13 age- and sex-matched controls. Paraneoplastic GA was defined as GA occurring within 6 months of the diagnosis of solid organ malignancy and/or persistent GA that resolved with cancer treatment. Results: Most cases of paraneoplastic GA were associated with lung cancer (4/7). The clinical and histopathological features of paraneoplastic and classic GA were similar. Compared to classic GA, paraneoplastic GA cases were more often generalized disease (6/7 vs 6/13), refractory to treatment, and had a perivascular inflammatory cell infiltrate (5/7 vs 2/13). All cases of paraneoplastic GA that underwent definitive treatment of their cancer improved. Limitations: Single-institution, retrospective review with a small sample size. Conclusion: Paraneoplastic GA is rare, similar to classic GA, and refractory to treatment. We advocate for age-appropriate screening in individuals with GA that is nonresponsive to multiple lines of systemic treatment and evaluating patients with concerning signs or symptoms for an underlying neoplasm.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American Academy of Dermatology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- granuloma annulare
- paraneoplastic
- solid organ malignancy
ASJC Scopus subject areas
- Dermatology
Cite this
Clinical and histopathologic features of paraneoplastic granuloma annulare in association with solid organ malignancies : A case–control study. / Mangold, Aaron; Cumsky, Helen J.L.; Costello, Collin M.; Xie, Daniel Y.; Buras, Matthew R.; Nelson, Steven A.; DiCaudo, David J.; Sekulic, Aleksandar D; Pittelkow, Mark R.
In: Journal of the American Academy of Dermatology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and histopathologic features of paraneoplastic granuloma annulare in association with solid organ malignancies
T2 - A case–control study
AU - Mangold, Aaron
AU - Cumsky, Helen J.L.
AU - Costello, Collin M.
AU - Xie, Daniel Y.
AU - Buras, Matthew R.
AU - Nelson, Steven A.
AU - DiCaudo, David J.
AU - Sekulic, Aleksandar D
AU - Pittelkow, Mark R.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Granuloma annulare (GA) is a granulomatous skin eruption rarely associated with cancer. We report seven cases of paraneoplastic GA in association with solid organ malignancy. Objective: To compare the clinical and histopathological features of paraneoplastic GA to case-matched controls of classic GA. Methods: Retrospective chart and histopathological review of 7 individuals and 13 age- and sex-matched controls. Paraneoplastic GA was defined as GA occurring within 6 months of the diagnosis of solid organ malignancy and/or persistent GA that resolved with cancer treatment. Results: Most cases of paraneoplastic GA were associated with lung cancer (4/7). The clinical and histopathological features of paraneoplastic and classic GA were similar. Compared to classic GA, paraneoplastic GA cases were more often generalized disease (6/7 vs 6/13), refractory to treatment, and had a perivascular inflammatory cell infiltrate (5/7 vs 2/13). All cases of paraneoplastic GA that underwent definitive treatment of their cancer improved. Limitations: Single-institution, retrospective review with a small sample size. Conclusion: Paraneoplastic GA is rare, similar to classic GA, and refractory to treatment. We advocate for age-appropriate screening in individuals with GA that is nonresponsive to multiple lines of systemic treatment and evaluating patients with concerning signs or symptoms for an underlying neoplasm.
AB - Background: Granuloma annulare (GA) is a granulomatous skin eruption rarely associated with cancer. We report seven cases of paraneoplastic GA in association with solid organ malignancy. Objective: To compare the clinical and histopathological features of paraneoplastic GA to case-matched controls of classic GA. Methods: Retrospective chart and histopathological review of 7 individuals and 13 age- and sex-matched controls. Paraneoplastic GA was defined as GA occurring within 6 months of the diagnosis of solid organ malignancy and/or persistent GA that resolved with cancer treatment. Results: Most cases of paraneoplastic GA were associated with lung cancer (4/7). The clinical and histopathological features of paraneoplastic and classic GA were similar. Compared to classic GA, paraneoplastic GA cases were more often generalized disease (6/7 vs 6/13), refractory to treatment, and had a perivascular inflammatory cell infiltrate (5/7 vs 2/13). All cases of paraneoplastic GA that underwent definitive treatment of their cancer improved. Limitations: Single-institution, retrospective review with a small sample size. Conclusion: Paraneoplastic GA is rare, similar to classic GA, and refractory to treatment. We advocate for age-appropriate screening in individuals with GA that is nonresponsive to multiple lines of systemic treatment and evaluating patients with concerning signs or symptoms for an underlying neoplasm.
KW - granuloma annulare
KW - paraneoplastic
KW - solid organ malignancy
UR - http://www.scopus.com/inward/record.url?scp=85053327922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053327922&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2018.06.022
DO - 10.1016/j.jaad.2018.06.022
M3 - Article
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
ER -