Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes

Sasha Taleban, Kathleen O. Stewart, Darrick K. Li, Prashant Singh, Darrell S. Pardi, Holly C. Sturgeon, Vijay Yajnik, Ramnik J. Xavier, Ashwin N. Ananthakrishnan, Hamed Khalili

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims: To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods: We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results: Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions: Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalDigestive Diseases and Sciences
DOIs
StateAccepted/In press - May 3 2016

Fingerprint

Ulcerative Colitis
Crohn Disease
Quality of Life
Phenotype
Colitis
Inflammatory Bowel Diseases
Registries

Keywords

  • Crohn’s disease
  • Inflammatory bowel disease
  • Quality of life
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Taleban, S., Stewart, K. O., Li, D. K., Singh, P., Pardi, D. S., Sturgeon, H. C., ... Khalili, H. (Accepted/In press). Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes. Digestive Diseases and Sciences, 1-9. https://doi.org/10.1007/s10620-016-4180-8

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes. / Taleban, Sasha; Stewart, Kathleen O.; Li, Darrick K.; Singh, Prashant; Pardi, Darrell S.; Sturgeon, Holly C.; Yajnik, Vijay; Xavier, Ramnik J.; Ananthakrishnan, Ashwin N.; Khalili, Hamed.

In: Digestive Diseases and Sciences, 03.05.2016, p. 1-9.

Research output: Contribution to journalArticle

Taleban, S, Stewart, KO, Li, DK, Singh, P, Pardi, DS, Sturgeon, HC, Yajnik, V, Xavier, RJ, Ananthakrishnan, AN & Khalili, H 2016, 'Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes', Digestive Diseases and Sciences, pp. 1-9. https://doi.org/10.1007/s10620-016-4180-8
Taleban, Sasha ; Stewart, Kathleen O. ; Li, Darrick K. ; Singh, Prashant ; Pardi, Darrell S. ; Sturgeon, Holly C. ; Yajnik, Vijay ; Xavier, Ramnik J. ; Ananthakrishnan, Ashwin N. ; Khalili, Hamed. / Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes. In: Digestive Diseases and Sciences. 2016 ; pp. 1-9.
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AU - Singh, Prashant

AU - Pardi, Darrell S.

AU - Sturgeon, Holly C.

AU - Yajnik, Vijay

AU - Xavier, Ramnik J.

AU - Ananthakrishnan, Ashwin N.

AU - Khalili, Hamed

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N2 - Background: Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims: To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods: We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results: Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions: Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.

AB - Background: Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims: To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods: We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results: Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions: Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.

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