Abstract
Circulating atrial natriuretic factor (ANF) is regulated by clearance receptors (ANFR-C). C-ANF-(4-23) is a ring-deleted analogue of ANF, which binds specifically to ANFR-C. The present studies were undertaken to determine total metabolic (TMCR), pulmonary (PCR), and renal clearance rates (RCR) of ANF in a group of seven mongrel dogs in chronic congestive heart failure (CHF) in comparison with a control group (n = 6). TMCR was not altered in CHF [1,534 ± 319 vs. control: 1,735 ± 208 ml/min; P = not significant (NS)] in association with an elevation of circulating endogenous ANF (206 ± 44 vs. control: 36 ± 10 pg/ml; P < 0.01). Infusion of C-ANF-(4- 23) reduced TMCR in both groups similarly (CHF: 753 ± 134 vs. control: 972 ± 156 ml/min; P = NS). PCR was lower in CHF (286 ± 431 vs. 1,672 ± 407 ml/min; P < 0.05), whereas RCR was not different (10 ± 24 vs. control: 15 ± 25 ml/min; P = NS). ANFR-C blockade did not facilitate urinary sodium excretion in CHF. These studies demonstrate that 1) TMCR does not contribute to elevated endogenous ANF in CHF; 2) total functional activity of the clearance receptor pathway is preserved in CHF; and 3) renal ANF metabolism and the clearance receptor pathway are not linked to the avid sodium retention and renal ANF resistance observed in chronic CHF.
Original language | English (US) |
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Pages (from-to) | R936-R943 |
Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
Volume | 266 |
Issue number | 3 35-3 |
DOIs | |
State | Published - 1994 |
Keywords
- atrial peptides
- clearance receptor
- congestive heart failure
- kidney
- lung
- metabolism
ASJC Scopus subject areas
- Physiology
- Physiology (medical)