Clearance receptor-mediated control of atrial natriuretic factor in experimental congestive heart failure

R. R. Brandt, M. M. Redfield, L. L. Aarhus, J. A. Lewicki, J. C. Burnett

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Circulating atrial natriuretic factor (ANF) is regulated by clearance receptors (ANFR-C). C-ANF-(4-23) is a ring-deleted analogue of ANF, which binds specifically to ANFR-C. The present studies were undertaken to determine total metabolic (TMCR), pulmonary (PCR), and renal clearance rates (RCR) of ANF in a group of seven mongrel dogs in chronic congestive heart failure (CHF) in comparison with a control group (n = 6). TMCR was not altered in CHF [1,534 ± 319 vs. control: 1,735 ± 208 ml/min; P = not significant (NS)] in association with an elevation of circulating endogenous ANF (206 ± 44 vs. control: 36 ± 10 pg/ml; P < 0.01). Infusion of C-ANF-(4- 23) reduced TMCR in both groups similarly (CHF: 753 ± 134 vs. control: 972 ± 156 ml/min; P = NS). PCR was lower in CHF (286 ± 431 vs. 1,672 ± 407 ml/min; P < 0.05), whereas RCR was not different (10 ± 24 vs. control: 15 ± 25 ml/min; P = NS). ANFR-C blockade did not facilitate urinary sodium excretion in CHF. These studies demonstrate that 1) TMCR does not contribute to elevated endogenous ANF in CHF; 2) total functional activity of the clearance receptor pathway is preserved in CHF; and 3) renal ANF metabolism and the clearance receptor pathway are not linked to the avid sodium retention and renal ANF resistance observed in chronic CHF.

Original languageEnglish (US)
Pages (from-to)R936-R943
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume266
Issue number3 35-3
DOIs
StatePublished - 1994

Keywords

  • atrial peptides
  • clearance receptor
  • congestive heart failure
  • kidney
  • lung
  • metabolism

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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