Clearance of the Janus Kinase 2 (JAK2) V617F mutation after allogeneic stem cell transplantation in a patient with myelofibrosis with myeloid metaplasia

Guillermo J. Ruiz-Argüelles, Javier Garcés-Eisele, Virginia Reyes-Núñez, Guillermo J. Ruiz-Delgado, Carlos Rosillo, John K. Camoriano

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A patient with myelofibrosis with myeloid metaplasia displaying the V617F mutation of the JAK2 gene was given an allogeneic stem cell transplantation using a reduced-intensity conditioning regimen. The patient engrafted, and as he became a chimera, the expression of the V617F mutation of the JAK2 gene decreased progressively until its disappearance. Accordingly, the concept of "molecular remission" of the myelofibrosis with myeloid metaplasia could be entertained and added to the categories of response to treatment which have been recently described.

Original languageEnglish (US)
Pages (from-to)400-402
Number of pages3
JournalAmerican journal of hematology
Volume82
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • Bone marrow transplantation
  • JAK2 V617F mutation
  • Molecular remission
  • Myelofibrosis with myeloid metaplasia

ASJC Scopus subject areas

  • Hematology

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