Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Roxana O. Carare, Roxana Aldea, Nivedita Agarwal, Brian J. Bacskai, Ingo Bechman, Delphine Boche, Guojun Bu, Diederik Bulters, Alt Clemens, Scott E. Counts, Mony de Leon, Per K. Eide, Silvia Fossati, Steven M. Greenberg, Edith Hamel, Cheryl A. Hawkes, Maya Koronyo-Hamaoui, Atticus H. Hainsworth, David Holtzman, Masafumi IharaAngela Jefferson, Raj N. Kalaria, Christopher M. Kipps, Katja M. Kanninen, Ville Leinonen, Jo Anne McLaurin, Scott Miners, Tarja Malm, James A.R. Nicoll, Fabrizio Piazza, Gesine Paul, Steven M. Rich, Satoshi Saito, Andy Shih, Henrieta Scholtzova, Heather Snyder, Peter Snyder, Finnbogi Rutur Thormodsson, Susanne J. van Veluw, Roy O. Weller, David J. Werring, Donna Wilcock, Mark R. Wilson, Berislav V. Zlokovic, Ajay Verma

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

Original languageEnglish (US)
Article numbere12053
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume12
Issue number1
DOIs
StatePublished - 2020

Keywords

  • IPAD
  • ISTAART
  • cerebrospinal fluid
  • clearance
  • interstitial fluid

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy'. Together they form a unique fingerprint.

Cite this