Clearance of hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular carcinoma

Tsung Teh Wu, Hey Chi Hsu, Ding Shinn Chen, Jin Chuan Sheu, Ih Jen Su, Shiu Ling Chen, Sou Ming Chuang

Research output: Contribution to journalArticle

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Abstract

The serum HBsAg in 4 chronic HBsAg carrier patients with hepatocellular carcinoma (HCC) cleared within 4-38 months after surgical resection of their hepatic tumors. Two patients developed anti-HBs. During the follow-up period from 21 to 28 months after HBsAg clearance, none of the patients regained positive serum HBsAg. Two patients who had had tissue HBsAg present, exclusively in the tumor, showed quick HBsAg clearance after resection. The other 2 patients had a delayed HBsAg clearance. One had tissue HBsAg in both the tumor and nontumoral liver. Only 1 patient had tissue HBsAg in the liver, but not in the tumor. During the same period of observation of 323 chronic HBsAg carriers, who had a variety of histologically-verified chronic liver diseases and were followed for more than 6 months, only 1 cleared the antigen. The spontaneous HBsAg clearance in our HBsAg carriers (1/323) was significantly lower than that (4/64) of HBsAg-positive HCC patients with tumor resection, P < 0.004. The mechanisms of HBsAg clearance in HCC patients after surgical resection of tumors are discussed.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Hepatology
Volume4
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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Hepatitis B Surface Antigens
Hepatocellular Carcinoma
Neoplasms
Chronic Hepatitis B
Liver
Serum
Liver Diseases
Chronic Disease
Observation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wu, T. T., Hsu, H. C., Chen, D. S., Sheu, J. C., Su, I. J., Chen, S. L., & Chuang, S. M. (1987). Clearance of hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular carcinoma. Journal of Hepatology, 4(1), 45-51. https://doi.org/10.1016/S0168-8278(87)80008-9

Clearance of hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular carcinoma. / Wu, Tsung Teh; Hsu, Hey Chi; Chen, Ding Shinn; Sheu, Jin Chuan; Su, Ih Jen; Chen, Shiu Ling; Chuang, Sou Ming.

In: Journal of Hepatology, Vol. 4, No. 1, 1987, p. 45-51.

Research output: Contribution to journalArticle

Wu, Tsung Teh ; Hsu, Hey Chi ; Chen, Ding Shinn ; Sheu, Jin Chuan ; Su, Ih Jen ; Chen, Shiu Ling ; Chuang, Sou Ming. / Clearance of hepatitis B surface antigen (HBsAg) after surgical resection of hepatocellular carcinoma. In: Journal of Hepatology. 1987 ; Vol. 4, No. 1. pp. 45-51.
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abstract = "The serum HBsAg in 4 chronic HBsAg carrier patients with hepatocellular carcinoma (HCC) cleared within 4-38 months after surgical resection of their hepatic tumors. Two patients developed anti-HBs. During the follow-up period from 21 to 28 months after HBsAg clearance, none of the patients regained positive serum HBsAg. Two patients who had had tissue HBsAg present, exclusively in the tumor, showed quick HBsAg clearance after resection. The other 2 patients had a delayed HBsAg clearance. One had tissue HBsAg in both the tumor and nontumoral liver. Only 1 patient had tissue HBsAg in the liver, but not in the tumor. During the same period of observation of 323 chronic HBsAg carriers, who had a variety of histologically-verified chronic liver diseases and were followed for more than 6 months, only 1 cleared the antigen. The spontaneous HBsAg clearance in our HBsAg carriers (1/323) was significantly lower than that (4/64) of HBsAg-positive HCC patients with tumor resection, P < 0.004. The mechanisms of HBsAg clearance in HCC patients after surgical resection of tumors are discussed.",
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AU - Su, Ih Jen

AU - Chen, Shiu Ling

AU - Chuang, Sou Ming

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AB - The serum HBsAg in 4 chronic HBsAg carrier patients with hepatocellular carcinoma (HCC) cleared within 4-38 months after surgical resection of their hepatic tumors. Two patients developed anti-HBs. During the follow-up period from 21 to 28 months after HBsAg clearance, none of the patients regained positive serum HBsAg. Two patients who had had tissue HBsAg present, exclusively in the tumor, showed quick HBsAg clearance after resection. The other 2 patients had a delayed HBsAg clearance. One had tissue HBsAg in both the tumor and nontumoral liver. Only 1 patient had tissue HBsAg in the liver, but not in the tumor. During the same period of observation of 323 chronic HBsAg carriers, who had a variety of histologically-verified chronic liver diseases and were followed for more than 6 months, only 1 cleared the antigen. The spontaneous HBsAg clearance in our HBsAg carriers (1/323) was significantly lower than that (4/64) of HBsAg-positive HCC patients with tumor resection, P < 0.004. The mechanisms of HBsAg clearance in HCC patients after surgical resection of tumors are discussed.

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