Classification, Diagnosis, and Management of Cholangiocarcinoma

Nataliya Razumilava, Gregory J. Gores

Research output: Contribution to journalReview article

150 Scopus citations

Abstract

Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. Classification of CCAs into intrahepatic, perihilar, and distal subgroups has helped standardize the registration, treatment, and study of this lethal malignancy. Physicians should remain aware that cirrhosis and viral hepatitis B and C are predisposing conditions for intrahepatic CCA. Treatment options under development include locoregional therapies and a chemotherapy regimen of gemcitabine and cisplatin. It is a challenge to diagnose perihilar CCA, but an advanced cytologic technique of fluorescence in situ hybridization for polysomy can aid in diagnosis. It is important to increase our understanding of the use of biliary stents and liver transplantation in the management of perihilar CCA, as well as to distinguish distal CCAs from pancreatic cancer, because of different outcomes from surgery. We review advances in the classification, diagnosis, and staging of CCA, along with treatment options.

Original languageEnglish (US)
Pages (from-to)13-21.el
JournalClinical Gastroenterology and Hepatology
Volume11
Issue number1
DOIs
StatePublished - Jan 2013

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Keywords

  • Distal Cholangiocarcinoma
  • Intrahepatic Cholangiocarcinoma
  • Perihilar Cholangiocarcinoma

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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