Classification, Diagnosis, and Management of Cholangiocarcinoma

Nataliya Razumilava, Gregory James Gores

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. Classification of CCAs into intrahepatic, perihilar, and distal subgroups has helped standardize the registration, treatment, and study of this lethal malignancy. Physicians should remain aware that cirrhosis and viral hepatitis B and C are predisposing conditions for intrahepatic CCA. Treatment options under development include locoregional therapies and a chemotherapy regimen of gemcitabine and cisplatin. It is a challenge to diagnose perihilar CCA, but an advanced cytologic technique of fluorescence in situ hybridization for polysomy can aid in diagnosis. It is important to increase our understanding of the use of biliary stents and liver transplantation in the management of perihilar CCA, as well as to distinguish distal CCAs from pancreatic cancer, because of different outcomes from surgery. We review advances in the classification, diagnosis, and staging of CCA, along with treatment options.

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
Volume11
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Cholangiocarcinoma
Klatskin Tumor
gemcitabine
Therapeutics
Biliary Tract
Hepatitis C
Hepatitis B
Fluorescence In Situ Hybridization
Pancreatic Neoplasms
Liver Transplantation
Cisplatin
Stents
Neoplasms
Fibrosis
Physicians
Drug Therapy

Keywords

  • Distal Cholangiocarcinoma
  • Intrahepatic Cholangiocarcinoma
  • Perihilar Cholangiocarcinoma

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Classification, Diagnosis, and Management of Cholangiocarcinoma. / Razumilava, Nataliya; Gores, Gregory James.

In: Clinical Gastroenterology and Hepatology, Vol. 11, No. 1, 01.2013.

Research output: Contribution to journalArticle

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