TY - JOUR
T1 - Classification, Diagnosis, and Management of Cholangiocarcinoma
AU - Razumilava, Nataliya
AU - Gores, Gregory J.
N1 - Funding Information:
Funding Supported by National Institutes of Health grants DK59427 (G.J.G.) and T32 DK007198 (N.R.), and the Mayo Foundation .
PY - 2013/1
Y1 - 2013/1
N2 - Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. Classification of CCAs into intrahepatic, perihilar, and distal subgroups has helped standardize the registration, treatment, and study of this lethal malignancy. Physicians should remain aware that cirrhosis and viral hepatitis B and C are predisposing conditions for intrahepatic CCA. Treatment options under development include locoregional therapies and a chemotherapy regimen of gemcitabine and cisplatin. It is a challenge to diagnose perihilar CCA, but an advanced cytologic technique of fluorescence in situ hybridization for polysomy can aid in diagnosis. It is important to increase our understanding of the use of biliary stents and liver transplantation in the management of perihilar CCA, as well as to distinguish distal CCAs from pancreatic cancer, because of different outcomes from surgery. We review advances in the classification, diagnosis, and staging of CCA, along with treatment options.
AB - Cholangiocarcinomas (CCAs) are tumors that develop along the biliary tract. Depending on their site of origin, they have different features and require specific treatments. Classification of CCAs into intrahepatic, perihilar, and distal subgroups has helped standardize the registration, treatment, and study of this lethal malignancy. Physicians should remain aware that cirrhosis and viral hepatitis B and C are predisposing conditions for intrahepatic CCA. Treatment options under development include locoregional therapies and a chemotherapy regimen of gemcitabine and cisplatin. It is a challenge to diagnose perihilar CCA, but an advanced cytologic technique of fluorescence in situ hybridization for polysomy can aid in diagnosis. It is important to increase our understanding of the use of biliary stents and liver transplantation in the management of perihilar CCA, as well as to distinguish distal CCAs from pancreatic cancer, because of different outcomes from surgery. We review advances in the classification, diagnosis, and staging of CCA, along with treatment options.
KW - Distal Cholangiocarcinoma
KW - Intrahepatic Cholangiocarcinoma
KW - Perihilar Cholangiocarcinoma
UR - http://www.scopus.com/inward/record.url?scp=84870879515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870879515&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2012.09.009
DO - 10.1016/j.cgh.2012.09.009
M3 - Review article
C2 - 22982100
AN - SCOPUS:84870879515
SN - 1542-3565
VL - 11
SP - 13-21.el
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 1
ER -