Classification and grading of low-grade astrocytic tumors in children

Caterina Giannini, Bernd W. Scheithauer

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected behavior and, more importantly, for guiding therapeutic intervention. For example, pleomorphic xanthoastrocytoma, which may exhibit 'anaplastic' features, generally carries a relatively favorable prognosis and should not be classified with other high-grade gliomas, such as anaplastic astrocytoma and glioblastoma multiforme. Similarly, the finding of anaplastic features, such as vascular proliferation or necrosis, in pilocytic astrocytomas does not automatically portend the unfavorable prognosis that such features would imply for 'diffuse' astrocytomas. Increased appreciation of the morphological diversity of astrocytomas in children should help to improve the management of children with low-grade astrocytic tumors by avoiding potentially dangerous overtreatment of otherwise indolent lesions.

Original languageEnglish (US)
Pages (from-to)785-798
Number of pages14
JournalBrain Pathology
Volume7
Issue number2
StatePublished - 1997
Externally publishedYes

Fingerprint

Astrocytoma
Neoplasms
Glioblastoma
Glioma
Blood Vessels
Necrosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

Classification and grading of low-grade astrocytic tumors in children. / Giannini, Caterina; Scheithauer, Bernd W.

In: Brain Pathology, Vol. 7, No. 2, 1997, p. 785-798.

Research output: Contribution to journalArticle

Giannini, Caterina ; Scheithauer, Bernd W. / Classification and grading of low-grade astrocytic tumors in children. In: Brain Pathology. 1997 ; Vol. 7, No. 2. pp. 785-798.
@article{bf1f9645c39e4e9099fa276c7689152c,
title = "Classification and grading of low-grade astrocytic tumors in children",
abstract = "This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected behavior and, more importantly, for guiding therapeutic intervention. For example, pleomorphic xanthoastrocytoma, which may exhibit 'anaplastic' features, generally carries a relatively favorable prognosis and should not be classified with other high-grade gliomas, such as anaplastic astrocytoma and glioblastoma multiforme. Similarly, the finding of anaplastic features, such as vascular proliferation or necrosis, in pilocytic astrocytomas does not automatically portend the unfavorable prognosis that such features would imply for 'diffuse' astrocytomas. Increased appreciation of the morphological diversity of astrocytomas in children should help to improve the management of children with low-grade astrocytic tumors by avoiding potentially dangerous overtreatment of otherwise indolent lesions.",
author = "Caterina Giannini and Scheithauer, {Bernd W.}",
year = "1997",
language = "English (US)",
volume = "7",
pages = "785--798",
journal = "Brain Pathology",
issn = "1015-6305",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Classification and grading of low-grade astrocytic tumors in children

AU - Giannini, Caterina

AU - Scheithauer, Bernd W.

PY - 1997

Y1 - 1997

N2 - This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected behavior and, more importantly, for guiding therapeutic intervention. For example, pleomorphic xanthoastrocytoma, which may exhibit 'anaplastic' features, generally carries a relatively favorable prognosis and should not be classified with other high-grade gliomas, such as anaplastic astrocytoma and glioblastoma multiforme. Similarly, the finding of anaplastic features, such as vascular proliferation or necrosis, in pilocytic astrocytomas does not automatically portend the unfavorable prognosis that such features would imply for 'diffuse' astrocytomas. Increased appreciation of the morphological diversity of astrocytomas in children should help to improve the management of children with low-grade astrocytic tumors by avoiding potentially dangerous overtreatment of otherwise indolent lesions.

AB - This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected behavior and, more importantly, for guiding therapeutic intervention. For example, pleomorphic xanthoastrocytoma, which may exhibit 'anaplastic' features, generally carries a relatively favorable prognosis and should not be classified with other high-grade gliomas, such as anaplastic astrocytoma and glioblastoma multiforme. Similarly, the finding of anaplastic features, such as vascular proliferation or necrosis, in pilocytic astrocytomas does not automatically portend the unfavorable prognosis that such features would imply for 'diffuse' astrocytomas. Increased appreciation of the morphological diversity of astrocytomas in children should help to improve the management of children with low-grade astrocytic tumors by avoiding potentially dangerous overtreatment of otherwise indolent lesions.

UR - http://www.scopus.com/inward/record.url?scp=0030957897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030957897&partnerID=8YFLogxK

M3 - Article

C2 - 9161729

AN - SCOPUS:0030957897

VL - 7

SP - 785

EP - 798

JO - Brain Pathology

JF - Brain Pathology

SN - 1015-6305

IS - 2

ER -