Class II antigen expression in peripheral neuropathies

G. W. Mitchell, G. S. Williams, E. P. Bosch, M. N. Hart

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The expression of class II antigen was studied in sural nerve biopsies from patients with peripheral neuropathies. These included patients with chronic demyelinating polyradiculoneuropathy (CIDP), non-immune mediated neuropathies of diverse etiologies and controls without evidence of neuropathy. The major finding in CIDP was a marked increase in class II expression on Schwann cells. Endoneurial Schwann cell staining to the same degree as in CIDP was seen in diabetic symmetric proximal motor neuropathy, neuropathies associated with monoclonal gammopathies and hereditary sensory and autonomic neuropathy type 1. In the control nerves and the other non-immune mediated neuropathies class II expression was mainly restricted to endothelial and perineurial cells. Increased endoneurial expression of class II antigen was found to correlate with elevated cerebrospinal fluid (CSF) protein levels but not with other clinical variables or demyelination as defined by electrophysiologic criteria or teased fiber analysis. The increased expression of class II antigen on Schwann cells may be indicative of a breakdown in immunological tolerance but should not be used as a diagnostic marker for dysimmune neuropathies due to overlap with non-immune mediated neuropathies.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalJournal of the Neurological Sciences
Volume102
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Polyradiculoneuropathy
Schwann Cells
Histocompatibility Antigens Class II
Peripheral Nervous System Diseases
Hereditary Sensory and Autonomic Neuropathies
Cerebrospinal Fluid Proteins
Sural Nerve
Paraproteinemias
Diabetic Neuropathies
Demyelinating Diseases
Endothelial Cells
Staining and Labeling
Biopsy

Keywords

  • Chronic demyelinating polyradiculoneuropathy
  • Class II antigen
  • Diabetic neuropathy
  • Monoclonal gammopathy
  • Neuropathy
  • Schwann cell

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Mitchell, G. W., Williams, G. S., Bosch, E. P., & Hart, M. N. (1991). Class II antigen expression in peripheral neuropathies. Journal of the Neurological Sciences, 102(2), 170-176. https://doi.org/10.1016/0022-510X(91)90065-F

Class II antigen expression in peripheral neuropathies. / Mitchell, G. W.; Williams, G. S.; Bosch, E. P.; Hart, M. N.

In: Journal of the Neurological Sciences, Vol. 102, No. 2, 1991, p. 170-176.

Research output: Contribution to journalArticle

Mitchell, GW, Williams, GS, Bosch, EP & Hart, MN 1991, 'Class II antigen expression in peripheral neuropathies', Journal of the Neurological Sciences, vol. 102, no. 2, pp. 170-176. https://doi.org/10.1016/0022-510X(91)90065-F
Mitchell, G. W. ; Williams, G. S. ; Bosch, E. P. ; Hart, M. N. / Class II antigen expression in peripheral neuropathies. In: Journal of the Neurological Sciences. 1991 ; Vol. 102, No. 2. pp. 170-176.
@article{b8278354324049e2aa3732240ee7768b,
title = "Class II antigen expression in peripheral neuropathies",
abstract = "The expression of class II antigen was studied in sural nerve biopsies from patients with peripheral neuropathies. These included patients with chronic demyelinating polyradiculoneuropathy (CIDP), non-immune mediated neuropathies of diverse etiologies and controls without evidence of neuropathy. The major finding in CIDP was a marked increase in class II expression on Schwann cells. Endoneurial Schwann cell staining to the same degree as in CIDP was seen in diabetic symmetric proximal motor neuropathy, neuropathies associated with monoclonal gammopathies and hereditary sensory and autonomic neuropathy type 1. In the control nerves and the other non-immune mediated neuropathies class II expression was mainly restricted to endothelial and perineurial cells. Increased endoneurial expression of class II antigen was found to correlate with elevated cerebrospinal fluid (CSF) protein levels but not with other clinical variables or demyelination as defined by electrophysiologic criteria or teased fiber analysis. The increased expression of class II antigen on Schwann cells may be indicative of a breakdown in immunological tolerance but should not be used as a diagnostic marker for dysimmune neuropathies due to overlap with non-immune mediated neuropathies.",
keywords = "Chronic demyelinating polyradiculoneuropathy, Class II antigen, Diabetic neuropathy, Monoclonal gammopathy, Neuropathy, Schwann cell",
author = "Mitchell, {G. W.} and Williams, {G. S.} and Bosch, {E. P.} and Hart, {M. N.}",
year = "1991",
doi = "10.1016/0022-510X(91)90065-F",
language = "English (US)",
volume = "102",
pages = "170--176",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Class II antigen expression in peripheral neuropathies

AU - Mitchell, G. W.

AU - Williams, G. S.

AU - Bosch, E. P.

AU - Hart, M. N.

PY - 1991

Y1 - 1991

N2 - The expression of class II antigen was studied in sural nerve biopsies from patients with peripheral neuropathies. These included patients with chronic demyelinating polyradiculoneuropathy (CIDP), non-immune mediated neuropathies of diverse etiologies and controls without evidence of neuropathy. The major finding in CIDP was a marked increase in class II expression on Schwann cells. Endoneurial Schwann cell staining to the same degree as in CIDP was seen in diabetic symmetric proximal motor neuropathy, neuropathies associated with monoclonal gammopathies and hereditary sensory and autonomic neuropathy type 1. In the control nerves and the other non-immune mediated neuropathies class II expression was mainly restricted to endothelial and perineurial cells. Increased endoneurial expression of class II antigen was found to correlate with elevated cerebrospinal fluid (CSF) protein levels but not with other clinical variables or demyelination as defined by electrophysiologic criteria or teased fiber analysis. The increased expression of class II antigen on Schwann cells may be indicative of a breakdown in immunological tolerance but should not be used as a diagnostic marker for dysimmune neuropathies due to overlap with non-immune mediated neuropathies.

AB - The expression of class II antigen was studied in sural nerve biopsies from patients with peripheral neuropathies. These included patients with chronic demyelinating polyradiculoneuropathy (CIDP), non-immune mediated neuropathies of diverse etiologies and controls without evidence of neuropathy. The major finding in CIDP was a marked increase in class II expression on Schwann cells. Endoneurial Schwann cell staining to the same degree as in CIDP was seen in diabetic symmetric proximal motor neuropathy, neuropathies associated with monoclonal gammopathies and hereditary sensory and autonomic neuropathy type 1. In the control nerves and the other non-immune mediated neuropathies class II expression was mainly restricted to endothelial and perineurial cells. Increased endoneurial expression of class II antigen was found to correlate with elevated cerebrospinal fluid (CSF) protein levels but not with other clinical variables or demyelination as defined by electrophysiologic criteria or teased fiber analysis. The increased expression of class II antigen on Schwann cells may be indicative of a breakdown in immunological tolerance but should not be used as a diagnostic marker for dysimmune neuropathies due to overlap with non-immune mediated neuropathies.

KW - Chronic demyelinating polyradiculoneuropathy

KW - Class II antigen

KW - Diabetic neuropathy

KW - Monoclonal gammopathy

KW - Neuropathy

KW - Schwann cell

UR - http://www.scopus.com/inward/record.url?scp=0025726830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025726830&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(91)90065-F

DO - 10.1016/0022-510X(91)90065-F

M3 - Article

C2 - 1649260

AN - SCOPUS:0025726830

VL - 102

SP - 170

EP - 176

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 2

ER -