Class C GPCRs in the airway

Brijeshkumar S. Patel, Jovanka Ravix, Christina Pabelick, Y. S. Prakash

Research output: Contribution to journalReview article

Abstract

Understanding and targeting of GPCRs remain a critical aspect of airway pharmacology and therapeutics for diseases such as asthma or COPD. Most attention has been on the large Class A GPCRs towards improved bronchodilation and blunting of remodeling. Better known in the central or peripheral nervous system, there is increasing evidence that Class C GPCRs which include metabotropic glutamate and GABA receptors, the calcium sensing receptor, sweet/umami taste receptors and a number of orphan receptors, can contribute to airway structure and function. In this review, we will summarize current state of knowledge regarding the pharmacology of Class C GPCRs, their expression and potential functions in the airways, and the application of pharmacological agents targeting this group in the context of airway diseases.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalCurrent Opinion in Pharmacology
Volume51
DOIs
StatePublished - Apr 2020

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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