TY - JOUR
T1 - Citalopram induced torsade de pointes, a rare life threatening side effect
AU - Kanjanauthai, Somsupha
AU - Kanluen, Tony
AU - Chareonthaitawee, Panithaya
PY - 2008/12/17
Y1 - 2008/12/17
N2 - Acquired Long QT syndrome is a disorder caused by medications, electrolyte imbalances, and drug interactions. This syndrome is associated with an increased risk of a characteristic life-threatening cardiac arrhythmia, known as torsade de pointes (TdP). In the setting of Long QT syndrome (LQTS), selective serotonin reuptake inhibitors (SSRIs) can precipitate TdP. We report the first case of LQTS and TdP induced by citalopram in the United States. After discontinuation of citalopram, the QT/QTc interval normalized after 3 days and resolved further episodes of TdP. Patients on citalopram should be monitored closely for QT/QTc interval to prevent torsade de pointes.
AB - Acquired Long QT syndrome is a disorder caused by medications, electrolyte imbalances, and drug interactions. This syndrome is associated with an increased risk of a characteristic life-threatening cardiac arrhythmia, known as torsade de pointes (TdP). In the setting of Long QT syndrome (LQTS), selective serotonin reuptake inhibitors (SSRIs) can precipitate TdP. We report the first case of LQTS and TdP induced by citalopram in the United States. After discontinuation of citalopram, the QT/QTc interval normalized after 3 days and resolved further episodes of TdP. Patients on citalopram should be monitored closely for QT/QTc interval to prevent torsade de pointes.
KW - Acquired Long QT syndrome
KW - Citalopram
KW - Selective serotonin reuptake inhibitors
KW - Torsade de pointes
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U2 - 10.1016/j.ijcard.2007.08.006
DO - 10.1016/j.ijcard.2007.08.006
M3 - Article
C2 - 17919753
AN - SCOPUS:56349148945
SN - 0167-5273
VL - 131
SP - e33-e34
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -