Cisplatin neuropathy: clinical course and neurophysiological findings

Mauro LoMonaco; Margherita Milone; Anna Paola Batocchi; Luca Padua; Domenico Restuccia; Pietro Tonali

doi:10.1007/BF00839140

Cisplatin neuropathy: clinical course and neurophysiological findings

Mauro LoMonaco, Margherita Milone, Anna Paola Batocchi, Luca Padua, Domenico Restuccia, Pietro Tonali

Neurology

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86 Scopus citations

Abstract

Sixteen patients treated with cisplatin (CDDP) 40 mg/m² on days 1-5 every 4 weeks for three courses (cumulative dose 600 mg/m²) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m²). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.

Original language	English (US)
Pages (from-to)	199-204
Number of pages	6
Journal	Journal of Neurology
Volume	239
Issue number	4
DOIs	https://doi.org/10.1007/BF00839140
State	Published - Apr 1 1992

Keywords

Cisplatin
Polyneuropathy
Sensory nerve conduction

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1007/BF00839140

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abstract = "Sixteen patients treated with cisplatin (CDDP) 40 mg/m2 on days 1-5 every 4 weeks for three courses (cumulative dose 600 mg/m2) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m2). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.",

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AU - LoMonaco, Mauro

AU - Milone, Margherita

AU - Batocchi, Anna Paola

AU - Padua, Luca

AU - Restuccia, Domenico

AU - Tonali, Pietro

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Cisplatin neuropathy: clinical course and neurophysiological findings

Abstract

Keywords

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