Cisplatin neuropathy: clinical course and neurophysiological findings

Mauro LoMonaco, Margherita Milone, Anna Paola Batocchi, Luca Padua, Domenico Restuccia, Pietro Tonali

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Sixteen patients treated with cisplatin (CDDP) 40 mg/m2 on days 1-5 every 4 weeks for three courses (cumulative dose 600 mg/m2) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m2). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalJournal of Neurology
Volume239
Issue number4
DOIs
StatePublished - Apr 1 1992

Keywords

  • Cisplatin
  • Polyneuropathy
  • Sensory nerve conduction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    LoMonaco, M., Milone, M., Batocchi, A. P., Padua, L., Restuccia, D., & Tonali, P. (1992). Cisplatin neuropathy: clinical course and neurophysiological findings. Journal of Neurology, 239(4), 199-204. https://doi.org/10.1007/BF00839140