TY - JOUR
T1 - Circumferential ablation of Barrett's esophagus that contains high-grade dysplasia
T2 - a U.S. multicenter registry
AU - Ganz, Robert A.
AU - Overholt, Bergein F.
AU - Sharma, Virender K.
AU - Fleischer, David E.
AU - Shaheen, Nicholas J.
AU - Lightdale, Charles J.
AU - Freeman, Stephen R.
AU - Pruitt, Ronald E.
AU - Urayama, Shiro M.
AU - Gress, Frank
AU - Pavey, Darren A.
AU - Branch, M. Stanley
AU - Savides, Thomas J.
AU - Chang, Kenneth J.
AU - Muthusamy, V. Raman
AU - Bohorfoush, Anthony G.
AU - Pace, Samuel C.
AU - DeMeester, Steven R.
AU - Eysselein, Viktor E.
AU - Panjehpour, Masoud
AU - Triadafilopoulos, George
PY - 2008/7
Y1 - 2008/7
N2 - Background: The management strategies for Barrett's esophagus (BE) that contains high-grade dysplasia (HGD) include intensive endoscopic surveillance, photodynamic therapy, thermal ablation, EMR, and esophagectomy. Objective: To assess the safety and effectiveness of endoscopic circumferential balloon-based ablation by using radiofrequency energy for treating BE HGD. Design: Multicenter U.S. registry. Setting: Sixteen academic and community centers; treatment period from September 2004 to March 2007. Patients: Patients with histologic evidence of intestinal metaplasia (IM) that contained HGD confirmed by at least 2 expert pathologists. A prior EMR was permitted, provided that residual HGD remained in the BE region for ablation. Intervention: Endoscopic circumferential ablation with follow-up esophageal biopsies to assess the histologic response to treatment. Outcomes: Histologic complete response (CR) end points: (1) all biopsy specimen fragments obtained at the last biopsy session were negative for HGD (CR-HGD), (2) all biopsy specimens were negative for any dysplasia (CR-D), and (3) all biopsy specimens were negative for IM (CR-IM). Results: A total of 142 patients (median age 66 years, interquartile range [IQR] 59-75 years) who had BE HGD (median length 6 cm, IQR 3-8 cm) underwent circumferential ablation (median 1 session, IQR 1-2). No serious adverse events were reported. There was 1 asymptomatic stricture and no buried glands. Ninety-two patients had at least 1 follow-up biopsy session (median follow-up 12 months, IQR 8-15 months). A CR-HGD was achieved in 90.2% of patients, CR-D in 80.4%, and CR-IM in 54.3%. Limitations: A nonrandomized study design, without a control arm, a lack of centralized pathology review, ablation and biopsy technique not standardized, and a relatively short-term follow-up. Conclusions: Endoscopic circumferential ablation is a promising modality for the treatment of BE that contains HGD. In this multicenter registry, the intervention safely achieved a CR for HGD in 90.2% of patients at a median of 12 months of follow-up.
AB - Background: The management strategies for Barrett's esophagus (BE) that contains high-grade dysplasia (HGD) include intensive endoscopic surveillance, photodynamic therapy, thermal ablation, EMR, and esophagectomy. Objective: To assess the safety and effectiveness of endoscopic circumferential balloon-based ablation by using radiofrequency energy for treating BE HGD. Design: Multicenter U.S. registry. Setting: Sixteen academic and community centers; treatment period from September 2004 to March 2007. Patients: Patients with histologic evidence of intestinal metaplasia (IM) that contained HGD confirmed by at least 2 expert pathologists. A prior EMR was permitted, provided that residual HGD remained in the BE region for ablation. Intervention: Endoscopic circumferential ablation with follow-up esophageal biopsies to assess the histologic response to treatment. Outcomes: Histologic complete response (CR) end points: (1) all biopsy specimen fragments obtained at the last biopsy session were negative for HGD (CR-HGD), (2) all biopsy specimens were negative for any dysplasia (CR-D), and (3) all biopsy specimens were negative for IM (CR-IM). Results: A total of 142 patients (median age 66 years, interquartile range [IQR] 59-75 years) who had BE HGD (median length 6 cm, IQR 3-8 cm) underwent circumferential ablation (median 1 session, IQR 1-2). No serious adverse events were reported. There was 1 asymptomatic stricture and no buried glands. Ninety-two patients had at least 1 follow-up biopsy session (median follow-up 12 months, IQR 8-15 months). A CR-HGD was achieved in 90.2% of patients, CR-D in 80.4%, and CR-IM in 54.3%. Limitations: A nonrandomized study design, without a control arm, a lack of centralized pathology review, ablation and biopsy technique not standardized, and a relatively short-term follow-up. Conclusions: Endoscopic circumferential ablation is a promising modality for the treatment of BE that contains HGD. In this multicenter registry, the intervention safely achieved a CR for HGD in 90.2% of patients at a median of 12 months of follow-up.
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U2 - 10.1016/j.gie.2007.12.015
DO - 10.1016/j.gie.2007.12.015
M3 - Article
C2 - 18355819
AN - SCOPUS:45249117528
SN - 0016-5107
VL - 68
SP - 35
EP - 40
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 1
ER -