TY - JOUR
T1 - Circulating sex hormones and terminal duct lobular unit involution of the normal breast
AU - Khodr, Zeina G.
AU - Sherman, Mark E.
AU - Pfeiffer, Ruth M.
AU - Gierach, Gretchen L.
AU - Brinton, Louise A.
AU - Falk, Roni T.
AU - Patel, Deesha A.
AU - Linville, Laura M.
AU - Papathomas, Daphne
AU - Clare, Susan E.
AU - Visscher, Daniel W.
AU - Mies, Carolyn
AU - Hewitt, Stephen M.
AU - Storniolo, Anna Maria V.
AU - Rosebrock, Adrian
AU - Caban, Jesus J.
AU - Figueroa, Jonine D.
N1 - Publisher Copyright:
© 2014 American Association for Cancer Research.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background: Terminal duct lobular units (TDLU) are the predominant source of breast cancers. Lesser degrees of age-related TDLU involution have been associated with increased breast cancer risk, but factors that influence involution are largely unknown. We assessed whether circulating hormones, implicated in breast cancer risk, are associated with levels of TDLU involution using data from the Susan G. Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Center (2009-2011).Methods: We evaluated three highly reproducible measures of TDLU involution, using normal breast tissue samples from the KTB (n = 390): TDLU counts, median TDLU span, and median acini counts per TDLU. RRs (for continuous measures), ORs (for categorical measures), 95% confidence intervals (95% CI), and Prends were calculated to assess the association between tertiles of estradiol, testosterone, sex hormone-binding globulin (SHBG), progesterone, and prolactin with TDLU measures. All models were stratified by menopausal status and adjusted for confounders.Results: Among premenopausal women, higher prolactin levels were associated with higher TDLU counts (RRT3vsT1:1.18; 95% CI: 1.07-1.31; Ptrend = 0.0005), but higher progesterone was associated with lower TDLU counts (RRT3vsT1: 0.80; 95% CI: 0.72-0.89; Ptrend < 0.0001). Among postmenopausal women, higher levels of estradiol (RRT3vsT1:1.61; 95% CI: 1.32-1.97; Ptrend < 0.0001) and testosterone (RRT3vsT1: 1.32; 95% CI: 1.09-1.59; Ptrend = 0.0043) were associated with higher TDLU counts.Conclusions: These data suggest that select hormones may influence breast cancer risk potentially through delaying TDLU involution.Impact: Increased understanding of the relationship between circulating markers and TDLU involution may offer new insights into breast carcinogenesis.
AB - Background: Terminal duct lobular units (TDLU) are the predominant source of breast cancers. Lesser degrees of age-related TDLU involution have been associated with increased breast cancer risk, but factors that influence involution are largely unknown. We assessed whether circulating hormones, implicated in breast cancer risk, are associated with levels of TDLU involution using data from the Susan G. Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Center (2009-2011).Methods: We evaluated three highly reproducible measures of TDLU involution, using normal breast tissue samples from the KTB (n = 390): TDLU counts, median TDLU span, and median acini counts per TDLU. RRs (for continuous measures), ORs (for categorical measures), 95% confidence intervals (95% CI), and Prends were calculated to assess the association between tertiles of estradiol, testosterone, sex hormone-binding globulin (SHBG), progesterone, and prolactin with TDLU measures. All models were stratified by menopausal status and adjusted for confounders.Results: Among premenopausal women, higher prolactin levels were associated with higher TDLU counts (RRT3vsT1:1.18; 95% CI: 1.07-1.31; Ptrend = 0.0005), but higher progesterone was associated with lower TDLU counts (RRT3vsT1: 0.80; 95% CI: 0.72-0.89; Ptrend < 0.0001). Among postmenopausal women, higher levels of estradiol (RRT3vsT1:1.61; 95% CI: 1.32-1.97; Ptrend < 0.0001) and testosterone (RRT3vsT1: 1.32; 95% CI: 1.09-1.59; Ptrend = 0.0043) were associated with higher TDLU counts.Conclusions: These data suggest that select hormones may influence breast cancer risk potentially through delaying TDLU involution.Impact: Increased understanding of the relationship between circulating markers and TDLU involution may offer new insights into breast carcinogenesis.
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U2 - 10.1158/1055-9965.EPI-14-0667
DO - 10.1158/1055-9965.EPI-14-0667
M3 - Article
C2 - 25472681
AN - SCOPUS:84919339726
SN - 1055-9965
VL - 23
SP - 2765
EP - 2773
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 12
ER -