Circulating osteogenic endothelial progenitor cell counts: new biomarker for the severity of coronary artery disease

Shi Wei Yang, Rebecca R. Hennessy, Sundeep Khosla, Ryan Lennon, Darrell Loeffler, Tao Sun, Zhi Liu, Kyoung Ha Park, Fei Long Wang, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34 −/CD133 +/KDR +) with osteogenic potential (OCN +) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN + CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). Methods Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40 months. Results OCN + early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95% confidence interval [CI]: 1.131 to 1.707, p = 0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95% CI: 1.157 to 1.582, p < 0.001). There was a weak tendency between OCN + early CEPC counts and all-cause mortality (p = 0.090), whereas the highest decile of OCN + early CEPC counts had a 2.991-fold increased risk of all-cause death (p = 0.047). Conclusions We demonstrate for the first time an independent, significant, and strong correlation between OCN + early CEPC counts and CAD severity. Additionally, very high numbers of OCN + early CEPC tend to be linked to the risk of all-cause mortality.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalInternational Journal of Cardiology
Volume227
DOIs
StatePublished - Jan 15 2017

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Coronary Artery Disease
Cell Count
Biomarkers
Coronary Stenosis
Cause of Death
Odds Ratio
Confidence Intervals
Vascular Calcification
Mortality
Endothelial Progenitor Cells
Coronary Angiography
Phenotype
Bone and Bones

Keywords

  • All-cause mortality
  • Circulating endothelial progenitor cells
  • Coronary artery disease severity
  • Osteocalcin

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine

Cite this

Circulating osteogenic endothelial progenitor cell counts : new biomarker for the severity of coronary artery disease. / Yang, Shi Wei; Hennessy, Rebecca R.; Khosla, Sundeep; Lennon, Ryan; Loeffler, Darrell; Sun, Tao; Liu, Zhi; Park, Kyoung Ha; Wang, Fei Long; Lerman, Lilach O; Lerman, Amir.

In: International Journal of Cardiology, Vol. 227, 15.01.2017, p. 833-839.

Research output: Contribution to journalArticle

Yang, Shi Wei ; Hennessy, Rebecca R. ; Khosla, Sundeep ; Lennon, Ryan ; Loeffler, Darrell ; Sun, Tao ; Liu, Zhi ; Park, Kyoung Ha ; Wang, Fei Long ; Lerman, Lilach O ; Lerman, Amir. / Circulating osteogenic endothelial progenitor cell counts : new biomarker for the severity of coronary artery disease. In: International Journal of Cardiology. 2017 ; Vol. 227. pp. 833-839.
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abstract = "Background There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34 −/CD133 +/KDR +) with osteogenic potential (OCN +) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN + CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). Methods Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40 months. Results OCN + early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95{\%} confidence interval [CI]: 1.131 to 1.707, p = 0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95{\%} CI: 1.157 to 1.582, p < 0.001). There was a weak tendency between OCN + early CEPC counts and all-cause mortality (p = 0.090), whereas the highest decile of OCN + early CEPC counts had a 2.991-fold increased risk of all-cause death (p = 0.047). Conclusions We demonstrate for the first time an independent, significant, and strong correlation between OCN + early CEPC counts and CAD severity. Additionally, very high numbers of OCN + early CEPC tend to be linked to the risk of all-cause mortality.",
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T1 - Circulating osteogenic endothelial progenitor cell counts

T2 - new biomarker for the severity of coronary artery disease

AU - Yang, Shi Wei

AU - Hennessy, Rebecca R.

AU - Khosla, Sundeep

AU - Lennon, Ryan

AU - Loeffler, Darrell

AU - Sun, Tao

AU - Liu, Zhi

AU - Park, Kyoung Ha

AU - Wang, Fei Long

AU - Lerman, Lilach O

AU - Lerman, Amir

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Background There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34 −/CD133 +/KDR +) with osteogenic potential (OCN +) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN + CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). Methods Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40 months. Results OCN + early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95% confidence interval [CI]: 1.131 to 1.707, p = 0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95% CI: 1.157 to 1.582, p < 0.001). There was a weak tendency between OCN + early CEPC counts and all-cause mortality (p = 0.090), whereas the highest decile of OCN + early CEPC counts had a 2.991-fold increased risk of all-cause death (p = 0.047). Conclusions We demonstrate for the first time an independent, significant, and strong correlation between OCN + early CEPC counts and CAD severity. Additionally, very high numbers of OCN + early CEPC tend to be linked to the risk of all-cause mortality.

AB - Background There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34 −/CD133 +/KDR +) with osteogenic potential (OCN +) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN + CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). Methods Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40 months. Results OCN + early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95% confidence interval [CI]: 1.131 to 1.707, p = 0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95% CI: 1.157 to 1.582, p < 0.001). There was a weak tendency between OCN + early CEPC counts and all-cause mortality (p = 0.090), whereas the highest decile of OCN + early CEPC counts had a 2.991-fold increased risk of all-cause death (p = 0.047). Conclusions We demonstrate for the first time an independent, significant, and strong correlation between OCN + early CEPC counts and CAD severity. Additionally, very high numbers of OCN + early CEPC tend to be linked to the risk of all-cause mortality.

KW - All-cause mortality

KW - Circulating endothelial progenitor cells

KW - Coronary artery disease severity

KW - Osteocalcin

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