Circulating osteogenic cells: Implications for injury, repair, and regeneration

Robert J. Pignolo; Moustapha Kassem

doi:10.1002/jbmr.370

Circulating osteogenic cells: Implications for injury, repair, and regeneration

Robert J. Pignolo, Moustapha Kassem

Hospital Internal Medicine

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid-phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues.

Original language	English (US)
Pages (from-to)	1685-1693
Number of pages	9
Journal	Journal of Bone and Mineral Research
Volume	26
Issue number	8
DOIs	https://doi.org/10.1002/jbmr.370
State	Published - Aug 2011

Keywords

blood
circulating osteogenic precursor cells
fracture
heterotopic ossification
mesenchymal stem cells

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

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10.1002/jbmr.370

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AB - The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid-phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues.

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KW - mesenchymal stem cells

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Circulating osteogenic cells: Implications for injury, repair, and regeneration

Abstract

Keywords

ASJC Scopus subject areas

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