Circulating microparticles and endogenous estrogen in newly menopausal women

M. Jayachandran, R. D. Litwiller, W. G. Owen, Virginia M Miller

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Estrogen modulates antithrombotic characteristics of the vascular endothelium and the interaction of blood elements with the vascular surface. A marker of these modulatory activities is formation of cell-specific microparticles. This study examined the relationship between blood-borne microparticles and endogenous estrogen at menopause. Methods: Platelet activation and plasma microparticles were characterized from women being screened (n = 146) for the Kronos Early Estrogen Prevention Study. Women were grouped according to serum estrogen (< 20 pg/ml; low estrogen, n = 21 or > 40 pg/ml; high estrogen, n = 11). Results: Age, body mass index, blood pressure and blood chemistries were the same in both groups. No woman was hypertensive, diabetic or a current smoker. Platelet counts, basal and activated expression of P-selectin on platelet membranes were the same, but activated expression of glycoprotein IIb/IIIa was greater in the high-estrogen group. Numbers of endothelium-, platelet-, monocyte- and granulocyte-derived microparticles were greater in the low-estrogen group. Of the total numbers of microparticles, those positive for phosphatidylserine and tissue factor were also greater in the low-estrogen group. Conclusion: These results suggest that, with declines in endogenous estrogen at menopause, numbers of procoagulant microparticles increase and thus may provide a means to explore mechanisms for cardiovascular risk development in newly menopausal women.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalClimacteric
Volume12
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Estrogens
Menopause
Platelet Count
Platelet Glycoprotein GPIIb-IIIa Complex
P-Selectin
Phosphatidylserines
Platelet Activation
Vascular Endothelium
Thromboplastin
Granulocytes
Endothelium
Blood Vessels
Monocytes
Body Mass Index
Blood Platelets
Blood Pressure
Membranes
Serum

Keywords

  • Menopause
  • Microvesicles
  • Phosphatidylserine
  • Sex hormone
  • Thrombosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Circulating microparticles and endogenous estrogen in newly menopausal women. / Jayachandran, M.; Litwiller, R. D.; Owen, W. G.; Miller, Virginia M.

In: Climacteric, Vol. 12, No. 2, 04.2009, p. 177-184.

Research output: Contribution to journalArticle

Jayachandran, M. ; Litwiller, R. D. ; Owen, W. G. ; Miller, Virginia M. / Circulating microparticles and endogenous estrogen in newly menopausal women. In: Climacteric. 2009 ; Vol. 12, No. 2. pp. 177-184.
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