Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus

The Multi-Ethnic Study of Atherosclerosis (MESA)

Michael P. Bancks, Suzette J Bielinski, Paul A. Decker, Naomi Q. Hanson, Nicholas Larson, Hugues Sicotte, Christina L. Wassel, James S. Pankow

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background Hepatocyte growth factor (HGF) is a pleotropic factor posited to have metabolic homeostatic properties. The purpose of this study is to examine whether level of HGF is associated with the development of type 2 diabetes. Methods Data from the Multi-Ethnic Study of Atherosclerosis (MESA) were used to examine the prospective association between serum level of HGF and incident diabetes. Fasting HGF was measured at Exam 1 (2000-2002) in 5395 participants free from diabetes (61.5 ± 10.2 years old) and incidence of diabetes was determined at four subsequent follow-up exams over 12 years. Hazard ratios (HR) for incident diabetes were estimated according to 1 standard deviation (SD) unit increment of HGF (1 SD = 26 μg/l), before and after adjustment for age, sex, race/ethnicity, education, study center, smoking status, alcohol consumption, body mass index, waist circumference, fasting glucose and insulin, C-reactive protein, and interleukin-6 levels. Results A 1 SD increment of baseline HGF was associated with a 46% (95% CI = 1.37, 1.56) increased risk of diabetes before adjustment. After adjustment, diabetes risk per 1 SD increment of HGF was attenuated but remained significantly increased (HR = 1.21; 95% CI = 1.12, 1.32). Men had a significantly greater HR compared to women per equivalent increase of HGF (p-value for sex interaction = 0.04). There was no evidence of effect modification by race/ethnicity. Conclusions This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume65
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Hepatocyte Growth Factor
Type 2 Diabetes Mellitus
Atherosclerosis
Incidence
Social Adjustment
Fasting
Waist Circumference
Alcohol Drinking
C-Reactive Protein
Insulin Resistance
Interleukin-6
Body Mass Index
Cross-Sectional Studies
Smoking
Insulin
Education
Glucose

Keywords

  • Diabetes mellitus
  • Ethnicity
  • Hepatocyte growth factor
  • Incidence
  • Longitudinal

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus : The Multi-Ethnic Study of Atherosclerosis (MESA). / Bancks, Michael P.; Bielinski, Suzette J; Decker, Paul A.; Hanson, Naomi Q.; Larson, Nicholas; Sicotte, Hugues; Wassel, Christina L.; Pankow, James S.

In: Metabolism: Clinical and Experimental, Vol. 65, No. 3, 01.03.2016, p. 64-72.

Research output: Contribution to journalArticle

Bancks, Michael P. ; Bielinski, Suzette J ; Decker, Paul A. ; Hanson, Naomi Q. ; Larson, Nicholas ; Sicotte, Hugues ; Wassel, Christina L. ; Pankow, James S. / Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus : The Multi-Ethnic Study of Atherosclerosis (MESA). In: Metabolism: Clinical and Experimental. 2016 ; Vol. 65, No. 3. pp. 64-72.
@article{f61de36adbc94ef0896cbea131a14ca0,
title = "Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA)",
abstract = "Background Hepatocyte growth factor (HGF) is a pleotropic factor posited to have metabolic homeostatic properties. The purpose of this study is to examine whether level of HGF is associated with the development of type 2 diabetes. Methods Data from the Multi-Ethnic Study of Atherosclerosis (MESA) were used to examine the prospective association between serum level of HGF and incident diabetes. Fasting HGF was measured at Exam 1 (2000-2002) in 5395 participants free from diabetes (61.5 ± 10.2 years old) and incidence of diabetes was determined at four subsequent follow-up exams over 12 years. Hazard ratios (HR) for incident diabetes were estimated according to 1 standard deviation (SD) unit increment of HGF (1 SD = 26 μg/l), before and after adjustment for age, sex, race/ethnicity, education, study center, smoking status, alcohol consumption, body mass index, waist circumference, fasting glucose and insulin, C-reactive protein, and interleukin-6 levels. Results A 1 SD increment of baseline HGF was associated with a 46{\%} (95{\%} CI = 1.37, 1.56) increased risk of diabetes before adjustment. After adjustment, diabetes risk per 1 SD increment of HGF was attenuated but remained significantly increased (HR = 1.21; 95{\%} CI = 1.12, 1.32). Men had a significantly greater HR compared to women per equivalent increase of HGF (p-value for sex interaction = 0.04). There was no evidence of effect modification by race/ethnicity. Conclusions This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism.",
keywords = "Diabetes mellitus, Ethnicity, Hepatocyte growth factor, Incidence, Longitudinal",
author = "Bancks, {Michael P.} and Bielinski, {Suzette J} and Decker, {Paul A.} and Hanson, {Naomi Q.} and Nicholas Larson and Hugues Sicotte and Wassel, {Christina L.} and Pankow, {James S.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.metabol.2015.10.023",
language = "English (US)",
volume = "65",
pages = "64--72",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus

T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)

AU - Bancks, Michael P.

AU - Bielinski, Suzette J

AU - Decker, Paul A.

AU - Hanson, Naomi Q.

AU - Larson, Nicholas

AU - Sicotte, Hugues

AU - Wassel, Christina L.

AU - Pankow, James S.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background Hepatocyte growth factor (HGF) is a pleotropic factor posited to have metabolic homeostatic properties. The purpose of this study is to examine whether level of HGF is associated with the development of type 2 diabetes. Methods Data from the Multi-Ethnic Study of Atherosclerosis (MESA) were used to examine the prospective association between serum level of HGF and incident diabetes. Fasting HGF was measured at Exam 1 (2000-2002) in 5395 participants free from diabetes (61.5 ± 10.2 years old) and incidence of diabetes was determined at four subsequent follow-up exams over 12 years. Hazard ratios (HR) for incident diabetes were estimated according to 1 standard deviation (SD) unit increment of HGF (1 SD = 26 μg/l), before and after adjustment for age, sex, race/ethnicity, education, study center, smoking status, alcohol consumption, body mass index, waist circumference, fasting glucose and insulin, C-reactive protein, and interleukin-6 levels. Results A 1 SD increment of baseline HGF was associated with a 46% (95% CI = 1.37, 1.56) increased risk of diabetes before adjustment. After adjustment, diabetes risk per 1 SD increment of HGF was attenuated but remained significantly increased (HR = 1.21; 95% CI = 1.12, 1.32). Men had a significantly greater HR compared to women per equivalent increase of HGF (p-value for sex interaction = 0.04). There was no evidence of effect modification by race/ethnicity. Conclusions This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism.

AB - Background Hepatocyte growth factor (HGF) is a pleotropic factor posited to have metabolic homeostatic properties. The purpose of this study is to examine whether level of HGF is associated with the development of type 2 diabetes. Methods Data from the Multi-Ethnic Study of Atherosclerosis (MESA) were used to examine the prospective association between serum level of HGF and incident diabetes. Fasting HGF was measured at Exam 1 (2000-2002) in 5395 participants free from diabetes (61.5 ± 10.2 years old) and incidence of diabetes was determined at four subsequent follow-up exams over 12 years. Hazard ratios (HR) for incident diabetes were estimated according to 1 standard deviation (SD) unit increment of HGF (1 SD = 26 μg/l), before and after adjustment for age, sex, race/ethnicity, education, study center, smoking status, alcohol consumption, body mass index, waist circumference, fasting glucose and insulin, C-reactive protein, and interleukin-6 levels. Results A 1 SD increment of baseline HGF was associated with a 46% (95% CI = 1.37, 1.56) increased risk of diabetes before adjustment. After adjustment, diabetes risk per 1 SD increment of HGF was attenuated but remained significantly increased (HR = 1.21; 95% CI = 1.12, 1.32). Men had a significantly greater HR compared to women per equivalent increase of HGF (p-value for sex interaction = 0.04). There was no evidence of effect modification by race/ethnicity. Conclusions This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism.

KW - Diabetes mellitus

KW - Ethnicity

KW - Hepatocyte growth factor

KW - Incidence

KW - Longitudinal

UR - http://www.scopus.com/inward/record.url?scp=84958225691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958225691&partnerID=8YFLogxK

U2 - 10.1016/j.metabol.2015.10.023

DO - 10.1016/j.metabol.2015.10.023

M3 - Article

VL - 65

SP - 64

EP - 72

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 3

ER -