Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)

J. S. Pankow, P. A. Decker, C. Berardi, N. Q. Hanson, M. Sale, W. Tang, A. M. Kanaya, Nicholas Larson, M. Y. Tsai, C. L. Wassel, Suzette J Bielinski

Research output: Contribution to journalArticle

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Abstract

Aims: To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes. Methods: Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes. Results: Sample sizes ranged from 826 to 2185. After adjusting for age, sex, race/ethnicity, BMI and fasting glucose or HbA1c, four cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1 and E-cadherin) were positively associated with incident diabetes and there was a statistically significant trend across quartiles. Comparing the incidence of diabetes in the highest and lowest quartiles of each cellular adhesion molecule, the magnitude of association was largest for E-selectin (hazard ratio 2.49; 95% CI 1.26–4.93) and ICAM-1 (hazard ratio 1.76; 95% CI 1.22–2.55) in fully adjusted models. Tests of effect modification by racial/ethnic group and sex were not statistically significant for any of the cellular adhesion molecules (P > 0.05). Conclusions: The finding of significant associations between multiple cellular adhesion molecules and incident diabetes may lend further support to the hypothesis that microvascular endothelial dysfunction contributes to risk of diabetes.

Original languageEnglish (US)
Pages (from-to)985-991
Number of pages7
JournalDiabetic Medicine
Volume33
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

E-Selectin
Intercellular Adhesion Molecule-1
Atherosclerosis
Vascular Cell Adhesion Molecule-1
Cadherins
L-Selectin
P-Selectin
Ethnic Groups
Sample Size
Fasting
Cohort Studies
Prospective Studies
Glucose
Incidence

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Circulating cellular adhesion molecules and risk of diabetes : the Multi-Ethnic Study of Atherosclerosis (MESA). / Pankow, J. S.; Decker, P. A.; Berardi, C.; Hanson, N. Q.; Sale, M.; Tang, W.; Kanaya, A. M.; Larson, Nicholas; Tsai, M. Y.; Wassel, C. L.; Bielinski, Suzette J.

In: Diabetic Medicine, Vol. 33, No. 7, 01.07.2016, p. 985-991.

Research output: Contribution to journalArticle

Pankow, JS, Decker, PA, Berardi, C, Hanson, NQ, Sale, M, Tang, W, Kanaya, AM, Larson, N, Tsai, MY, Wassel, CL & Bielinski, SJ 2016, 'Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)', Diabetic Medicine, vol. 33, no. 7, pp. 985-991. https://doi.org/10.1111/dme.13108
Pankow, J. S. ; Decker, P. A. ; Berardi, C. ; Hanson, N. Q. ; Sale, M. ; Tang, W. ; Kanaya, A. M. ; Larson, Nicholas ; Tsai, M. Y. ; Wassel, C. L. ; Bielinski, Suzette J. / Circulating cellular adhesion molecules and risk of diabetes : the Multi-Ethnic Study of Atherosclerosis (MESA). In: Diabetic Medicine. 2016 ; Vol. 33, No. 7. pp. 985-991.
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AU - Pankow, J. S.

AU - Decker, P. A.

AU - Berardi, C.

AU - Hanson, N. Q.

AU - Sale, M.

AU - Tang, W.

AU - Kanaya, A. M.

AU - Larson, Nicholas

AU - Tsai, M. Y.

AU - Wassel, C. L.

AU - Bielinski, Suzette J

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AB - Aims: To test the hypothesis that soluble cellular adhesion molecules would be positively and independently associated with risk of diabetes. Methods: Soluble levels of six cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin and P-selectin) were measured in participants in the Multi-Ethnic Study of Atherosclerosis, a prospective cohort study. Participants were then followed for up to 10 years to ascertain incident diabetes. Results: Sample sizes ranged from 826 to 2185. After adjusting for age, sex, race/ethnicity, BMI and fasting glucose or HbA1c, four cellular adhesion molecules (ICAM-1, E-selectin, VCAM-1 and E-cadherin) were positively associated with incident diabetes and there was a statistically significant trend across quartiles. Comparing the incidence of diabetes in the highest and lowest quartiles of each cellular adhesion molecule, the magnitude of association was largest for E-selectin (hazard ratio 2.49; 95% CI 1.26–4.93) and ICAM-1 (hazard ratio 1.76; 95% CI 1.22–2.55) in fully adjusted models. Tests of effect modification by racial/ethnic group and sex were not statistically significant for any of the cellular adhesion molecules (P > 0.05). Conclusions: The finding of significant associations between multiple cellular adhesion molecules and incident diabetes may lend further support to the hypothesis that microvascular endothelial dysfunction contributes to risk of diabetes.

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