@article{3b7ace6d76194b0ba630b9a06bac149d,
title = "Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer",
abstract = "Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.",
keywords = "NGS, circulating tumor DNA, copy number loss, liquid biopsy, prostate cancer",
author = "Xiaoxi Dong and Tiantian Zheng and Minhua Zhang and Chao Dai and Lili Wang and Lei Wang and Ruipeng Zhang and Yuan Long and Danyi Wen and Feng Xie and Yue Zhang and Yong Huang and Jianguo Dong and Huan Liu and Pan Du and King, {Bonnie L.} and Winston Tan and Shidong Jia and Lu, {Chris X.} and Manish Kohli and Haitao Wang and Jianjun Yu",
note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Dong, Zheng, Zhang, Dai, Wang, Wang, Zhang, Long, Wen, Xie, Zhang, Huang, Dong, Liu, Du, King, Tan, Jia, Lu, Kohli, Wang and Yu.",
year = "2021",
month = aug,
day = "24",
doi = "10.3389/fonc.2021.720727",
language = "English (US)",
volume = "11",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",
}