Circadian rhythm of appropriate implantable cardioverter defibrillator discharges in patients with hypertrophic cardiomyopathy

Thomas J. Kiernan, Peggy L. Weivoda, Virend Somers, Steve R. Ommen, Bernard J. Gersh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims: To characterize the circadian pattern of implantable cardioverter defibrillators (ICD) discharges in patients with hypertrophic cardiomyopathy (HCM) without previous surgical myectomy or percutaneous alcohol septal ablation. Methods and Results: HCM patients without previous surgical myectomy or percutaneous alcohol septal ablation having undergone ICD insertion at Mayo Clinic from 1992 to 2005 were studied. Analysis of appropriate ICD discharges with respect to time of day was performed. During a mean follow-up of 4.4 ± 4 years (P = 0.02), a total of 122 appropriate discharges were recorded. The average event rate for this group of patients was 4.3% per year. The circadian pattern reveals a pronounced peak in ICD discharges for the hours from 14:00 to 16:00. HCM patients receiving antiarrhythmic or β-blocker therapy did not demonstrate a different circadian pattern compared with patients not receiving these medications. Conclusion: Analysis of the temporal distribution of ICD discharges in HCM patients without previous surgical myectomy or percutaneous alcohol septal ablation reveals a peak occurrence of ICD discharges during the period from 12:00 to 18:00 hours with the highest incidence between 14:00 and 16:00 hours. This is different from the well-documented early morning peak observed in ischemic dilated cardiomyopathy patients.

Original languageEnglish (US)
Pages (from-to)1253-1258
Number of pages6
JournalPACE - Pacing and Clinical Electrophysiology
Volume31
Issue number10
DOIs
StatePublished - Oct 2008

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Implantable Defibrillators
Patient Discharge
Hypertrophic Cardiomyopathy
Circadian Rhythm
Alcohols
Dilated Cardiomyopathy
Incidence

Keywords

  • Databases
  • Defibrillation
  • ICD

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Circadian rhythm of appropriate implantable cardioverter defibrillator discharges in patients with hypertrophic cardiomyopathy. / Kiernan, Thomas J.; Weivoda, Peggy L.; Somers, Virend; Ommen, Steve R.; Gersh, Bernard J.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 31, No. 10, 10.2008, p. 1253-1258.

Research output: Contribution to journalArticle

Kiernan, Thomas J. ; Weivoda, Peggy L. ; Somers, Virend ; Ommen, Steve R. ; Gersh, Bernard J. / Circadian rhythm of appropriate implantable cardioverter defibrillator discharges in patients with hypertrophic cardiomyopathy. In: PACE - Pacing and Clinical Electrophysiology. 2008 ; Vol. 31, No. 10. pp. 1253-1258.
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