TY - JOUR
T1 - Ciliated adenocarcinoma of the ovary with evidence of serous differentiation
T2 - Report of a case
AU - Sciallis, Andrew Peter
AU - Aubry, Marie Christine
AU - Bell, Debra A.
PY - 2009/9
Y1 - 2009/9
N2 - A patient with bilateral ovarian adenocarcinomas composed predominantly of ciliated cells incidentally found at autopsy is reported. Although obviously malignant, a majority of the cells expressed well-differentiated cilia with terminal bar formation. In one of the masses, the neoplastic cells seemed to arise from a serous adenofibroma. The tumor was confined to the ovaries without evidence of metastatic spread. Although morphologically resembling an endometrioid-type neoplasm, immunohistochemical and molecular studies were more consistent with a serous phenotype, especially in light of its apparent origination from a serous adenofibroma. We agree with previous observations suggesting that although the neoplasm seems morphologically worrisome, it may actually portend a more benign clinical course.
AB - A patient with bilateral ovarian adenocarcinomas composed predominantly of ciliated cells incidentally found at autopsy is reported. Although obviously malignant, a majority of the cells expressed well-differentiated cilia with terminal bar formation. In one of the masses, the neoplastic cells seemed to arise from a serous adenofibroma. The tumor was confined to the ovaries without evidence of metastatic spread. Although morphologically resembling an endometrioid-type neoplasm, immunohistochemical and molecular studies were more consistent with a serous phenotype, especially in light of its apparent origination from a serous adenofibroma. We agree with previous observations suggesting that although the neoplasm seems morphologically worrisome, it may actually portend a more benign clinical course.
KW - Cilia
KW - Endometrioid
KW - Ovarian ciliated adenocarcinoma
KW - Serous adenofibroma
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U2 - 10.1097/PGP.0b013e3181a0717f
DO - 10.1097/PGP.0b013e3181a0717f
M3 - Article
C2 - 19696614
AN - SCOPUS:69749104966
SN - 0277-1691
VL - 28
SP - 447
EP - 452
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 5
ER -