Cigarette smoking and risk of celiac disease: A systematic review and meta-analysis

Karn Wijarnpreecha, Susan Lou, Panadeekarn Panjawatanan, Wisit Cheungpasitporn, Surakit Pungpapong, Frank J. Lukens, Patompong Ungprasert

Research output: Contribution to journalReview article

Abstract

Background/Objectives: A negative association between cigarette smoking and celiac disease has been observed but results were inconsistent across the published studies. A meta-analysis was conducted with the aim to identify all studies that investigated this association and to summarize the results of those studies. Methods: A comprehensive literature review was conducted utilizing MEDLINE and Embase databases through March 2018 to identify all cohort studies and case-control studies that compared the risk of celiac disease among current and/or former smokers versus never-smokers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of seven studies with 307,924 participants fulfilled the eligibility criteria and were included in the meta-analysis. The pooled analysis found a significantly decreased risk of celiac disease among current smokers compared with never-smokers with the pooled odds ratio (OR) of 0.52 (95% confidence interval (CI), 0.32–0.84; I2 86%). However, the risk of celiac disease among former smokers was not significantly different from never-smokers with the pooled OR of 1.10 (95% CI, 0.76–1.60; I2 of 73%). Conclusions: A significantly decreased risk of celiac disease among current smokers compared with never-smokers was demonstrated in this meta-analysis.

Original languageEnglish (US)
Pages (from-to)1285-1293
Number of pages9
JournalUnited European Gastroenterology Journal
Volume6
Issue number9
DOIs
StatePublished - Nov 1 2018

Keywords

  • Gluten enteropathy
  • celiac disease
  • meta-analysis
  • smoking
  • tobacco

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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    Wijarnpreecha, K., Lou, S., Panjawatanan, P., Cheungpasitporn, W., Pungpapong, S., Lukens, F. J., & Ungprasert, P. (2018). Cigarette smoking and risk of celiac disease: A systematic review and meta-analysis. United European Gastroenterology Journal, 6(9), 1285-1293. https://doi.org/10.1177/2050640618786790