TY - JOUR
T1 - Cigarette smoking and risk of celiac disease
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Lou, Susan
AU - Panjawatanan, Panadeekarn
AU - Cheungpasitporn, Wisit
AU - Pungpapong, Surakit
AU - Lukens, Frank J.
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© Author(s) 2018.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background/Objectives: A negative association between cigarette smoking and celiac disease has been observed but results were inconsistent across the published studies. A meta-analysis was conducted with the aim to identify all studies that investigated this association and to summarize the results of those studies. Methods: A comprehensive literature review was conducted utilizing MEDLINE and Embase databases through March 2018 to identify all cohort studies and case-control studies that compared the risk of celiac disease among current and/or former smokers versus never-smokers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of seven studies with 307,924 participants fulfilled the eligibility criteria and were included in the meta-analysis. The pooled analysis found a significantly decreased risk of celiac disease among current smokers compared with never-smokers with the pooled odds ratio (OR) of 0.52 (95% confidence interval (CI), 0.32–0.84; I2 86%). However, the risk of celiac disease among former smokers was not significantly different from never-smokers with the pooled OR of 1.10 (95% CI, 0.76–1.60; I2 of 73%). Conclusions: A significantly decreased risk of celiac disease among current smokers compared with never-smokers was demonstrated in this meta-analysis.
AB - Background/Objectives: A negative association between cigarette smoking and celiac disease has been observed but results were inconsistent across the published studies. A meta-analysis was conducted with the aim to identify all studies that investigated this association and to summarize the results of those studies. Methods: A comprehensive literature review was conducted utilizing MEDLINE and Embase databases through March 2018 to identify all cohort studies and case-control studies that compared the risk of celiac disease among current and/or former smokers versus never-smokers. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of seven studies with 307,924 participants fulfilled the eligibility criteria and were included in the meta-analysis. The pooled analysis found a significantly decreased risk of celiac disease among current smokers compared with never-smokers with the pooled odds ratio (OR) of 0.52 (95% confidence interval (CI), 0.32–0.84; I2 86%). However, the risk of celiac disease among former smokers was not significantly different from never-smokers with the pooled OR of 1.10 (95% CI, 0.76–1.60; I2 of 73%). Conclusions: A significantly decreased risk of celiac disease among current smokers compared with never-smokers was demonstrated in this meta-analysis.
KW - Gluten enteropathy
KW - celiac disease
KW - meta-analysis
KW - smoking
KW - tobacco
UR - http://www.scopus.com/inward/record.url?scp=85049672830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049672830&partnerID=8YFLogxK
U2 - 10.1177/2050640618786790
DO - 10.1177/2050640618786790
M3 - Review article
AN - SCOPUS:85049672830
SN - 2050-6406
VL - 6
SP - 1285
EP - 1293
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
IS - 9
ER -