Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer

An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

P. Bertuccio, C. La Vecchia, D. T. Silverman, Gloria M Petersen, P. M. Bracci, E. Negri, D. Li, H. A. Risch, S. H. Olson, S. Gallinger, A. B. Miller, H. B. Bueno-de-Mesquita, R. Talamini, J. Polesel, P. Ghadirian, P. A. Baghurst, W. Zatonski, E. T. Fontham, W. R. Bamlet, E. A. Holly & 10 others E. Lucenteforte, M. Hassan, H. Yu, R. C. Kurtz, M. Cotterchio, J. Su, P. Maisonneuve, E. J. Duell, C. Bosetti, P. Boffetta

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.

Original languageEnglish (US)
Pages (from-to)1420-1426
Number of pages7
JournalAnnals of Oncology
Volume22
Issue number6
DOIs
StatePublished - 2011

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Smokeless Tobacco
Tobacco Use
Pancreatic Neoplasms
Smoking
Odds Ratio
Tobacco Products
Confidence Intervals
Tobacco
Logistic Models
Case-Control Studies

Keywords

  • Cigar
  • Pancreatic cancer
  • Pipe
  • Pooled analysis
  • Smokeless tobacco
  • Tobacco

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer : An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). / Bertuccio, P.; La Vecchia, C.; Silverman, D. T.; Petersen, Gloria M; Bracci, P. M.; Negri, E.; Li, D.; Risch, H. A.; Olson, S. H.; Gallinger, S.; Miller, A. B.; Bueno-de-Mesquita, H. B.; Talamini, R.; Polesel, J.; Ghadirian, P.; Baghurst, P. A.; Zatonski, W.; Fontham, E. T.; Bamlet, W. R.; Holly, E. A.; Lucenteforte, E.; Hassan, M.; Yu, H.; Kurtz, R. C.; Cotterchio, M.; Su, J.; Maisonneuve, P.; Duell, E. J.; Bosetti, C.; Boffetta, P.

In: Annals of Oncology, Vol. 22, No. 6, 2011, p. 1420-1426.

Research output: Contribution to journalArticle

Bertuccio, P, La Vecchia, C, Silverman, DT, Petersen, GM, Bracci, PM, Negri, E, Li, D, Risch, HA, Olson, SH, Gallinger, S, Miller, AB, Bueno-de-Mesquita, HB, Talamini, R, Polesel, J, Ghadirian, P, Baghurst, PA, Zatonski, W, Fontham, ET, Bamlet, WR, Holly, EA, Lucenteforte, E, Hassan, M, Yu, H, Kurtz, RC, Cotterchio, M, Su, J, Maisonneuve, P, Duell, EJ, Bosetti, C & Boffetta, P 2011, 'Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)', Annals of Oncology, vol. 22, no. 6, pp. 1420-1426. https://doi.org/10.1093/annonc/mdq613
Bertuccio, P. ; La Vecchia, C. ; Silverman, D. T. ; Petersen, Gloria M ; Bracci, P. M. ; Negri, E. ; Li, D. ; Risch, H. A. ; Olson, S. H. ; Gallinger, S. ; Miller, A. B. ; Bueno-de-Mesquita, H. B. ; Talamini, R. ; Polesel, J. ; Ghadirian, P. ; Baghurst, P. A. ; Zatonski, W. ; Fontham, E. T. ; Bamlet, W. R. ; Holly, E. A. ; Lucenteforte, E. ; Hassan, M. ; Yu, H. ; Kurtz, R. C. ; Cotterchio, M. ; Su, J. ; Maisonneuve, P. ; Duell, E. J. ; Bosetti, C. ; Boffetta, P. / Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer : An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). In: Annals of Oncology. 2011 ; Vol. 22, No. 6. pp. 1420-1426.
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abstract = "Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95{\%} confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95{\%} CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95{\%} CI 1.4-1.6). The OR was 1.1 (95{\%} CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95{\%} CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.",
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author = "P. Bertuccio and {La Vecchia}, C. and Silverman, {D. T.} and Petersen, {Gloria M} and Bracci, {P. M.} and E. Negri and D. Li and Risch, {H. A.} and Olson, {S. H.} and S. Gallinger and Miller, {A. B.} and Bueno-de-Mesquita, {H. B.} and R. Talamini and J. Polesel and P. Ghadirian and Baghurst, {P. A.} and W. Zatonski and Fontham, {E. T.} and Bamlet, {W. R.} and Holly, {E. A.} and E. Lucenteforte and M. Hassan and H. Yu and Kurtz, {R. C.} and M. Cotterchio and J. Su and P. Maisonneuve and Duell, {E. J.} and C. Bosetti and P. Boffetta",
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T1 - Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer

T2 - An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

AU - Bertuccio, P.

AU - La Vecchia, C.

AU - Silverman, D. T.

AU - Petersen, Gloria M

AU - Bracci, P. M.

AU - Negri, E.

AU - Li, D.

AU - Risch, H. A.

AU - Olson, S. H.

AU - Gallinger, S.

AU - Miller, A. B.

AU - Bueno-de-Mesquita, H. B.

AU - Talamini, R.

AU - Polesel, J.

AU - Ghadirian, P.

AU - Baghurst, P. A.

AU - Zatonski, W.

AU - Fontham, E. T.

AU - Bamlet, W. R.

AU - Holly, E. A.

AU - Lucenteforte, E.

AU - Hassan, M.

AU - Yu, H.

AU - Kurtz, R. C.

AU - Cotterchio, M.

AU - Su, J.

AU - Maisonneuve, P.

AU - Duell, E. J.

AU - Bosetti, C.

AU - Boffetta, P.

PY - 2011

Y1 - 2011

N2 - Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.

AB - Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.

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KW - Pancreatic cancer

KW - Pipe

KW - Pooled analysis

KW - Smokeless tobacco

KW - Tobacco

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