Abstract
Progressive multifocal leukoencephalopathy (PML), a frequently fatal demyelinating disease caused by JC virus, occurs as an opportunistic infection in patients with acquired immunodeficiency syndrome. Curative therapy has been elusive, but recent reports suggest its improvement after institution of highly active antiretroviral therapy (HAART). We describe a case of PML that developed 6 months after the patient, a 55-year-old man, began to receive HAART. The PML progressed despite good virologic and immunologic response to HAART. Substantial symptomatic and radiographic improvement occurred after the addition of cidofovir to the treatment regimen. We reviewed the scientific literature on this rare occurrence of PML after institution of HAART and describe the patient characteristics, potential pathogenesis, and therapeutic options, including the successful use of cidofovir as an adjunctive agent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1171-1175 |
| Number of pages | 5 |
| Journal | Mayo Clinic Proceedings |
| Volume | 76 |
| Issue number | 11 |
| State | Published - 2001 |
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Keywords
- AIDS = acquired immunodeficiency syndrome
- CSF = cerebrospinal fluid
- HAART = highly active antiretroviral therapy
- HIV = human immunodeficiency virus
- JCV = JC virus
- MRI = magnetic resonance imaging
- PCR = polymerase chain reaction
- PI = protease inhibitor
- PML = progressive multifocal leukoencephalopathy
ASJC Scopus subject areas
- Medicine(all)
Cite this
Cidofovir treatment of progressive multifocal leukoencephalopathy in a patient receiving highly active antiretroviral therapy. / Razonable, Raymund R; Aksamit, Allen Jr.; Wright, A. J.; Wilson, J. W.
In: Mayo Clinic Proceedings, Vol. 76, No. 11, 2001, p. 1171-1175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cidofovir treatment of progressive multifocal leukoencephalopathy in a patient receiving highly active antiretroviral therapy
AU - Razonable, Raymund R
AU - Aksamit, Allen Jr.
AU - Wright, A. J.
AU - Wilson, J. W.
PY - 2001
Y1 - 2001
N2 - Progressive multifocal leukoencephalopathy (PML), a frequently fatal demyelinating disease caused by JC virus, occurs as an opportunistic infection in patients with acquired immunodeficiency syndrome. Curative therapy has been elusive, but recent reports suggest its improvement after institution of highly active antiretroviral therapy (HAART). We describe a case of PML that developed 6 months after the patient, a 55-year-old man, began to receive HAART. The PML progressed despite good virologic and immunologic response to HAART. Substantial symptomatic and radiographic improvement occurred after the addition of cidofovir to the treatment regimen. We reviewed the scientific literature on this rare occurrence of PML after institution of HAART and describe the patient characteristics, potential pathogenesis, and therapeutic options, including the successful use of cidofovir as an adjunctive agent.
AB - Progressive multifocal leukoencephalopathy (PML), a frequently fatal demyelinating disease caused by JC virus, occurs as an opportunistic infection in patients with acquired immunodeficiency syndrome. Curative therapy has been elusive, but recent reports suggest its improvement after institution of highly active antiretroviral therapy (HAART). We describe a case of PML that developed 6 months after the patient, a 55-year-old man, began to receive HAART. The PML progressed despite good virologic and immunologic response to HAART. Substantial symptomatic and radiographic improvement occurred after the addition of cidofovir to the treatment regimen. We reviewed the scientific literature on this rare occurrence of PML after institution of HAART and describe the patient characteristics, potential pathogenesis, and therapeutic options, including the successful use of cidofovir as an adjunctive agent.
KW - AIDS = acquired immunodeficiency syndrome
KW - CSF = cerebrospinal fluid
KW - HAART = highly active antiretroviral therapy
KW - HIV = human immunodeficiency virus
KW - JCV = JC virus
KW - MRI = magnetic resonance imaging
KW - PCR = polymerase chain reaction
KW - PI = protease inhibitor
KW - PML = progressive multifocal leukoencephalopathy
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M3 - Article
VL - 76
SP - 1171
EP - 1175
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 11
ER -