Chronic tetanus: Clinical report and histochemistry of muscle

Winthrop S. Risk, E. Peter Bosch, Jun Kimura, Pasquale A. Cancilla, Kenneth H. Fischbeck, Robert B. Layzer

Research output: Contribution to journalArticle

28 Scopus citations


A patient who was partially immune to tetanus developed nonfulminant tetanus after a minor injury. Manifestations of the disease persisted for over 17 months. Electrophysiologic studies revealed an absent silent period in the masseter muscle, large‐amplitude F‐responses, and denervation. A muscle biopsy showed neurogenic atrophy with reinnervation. This observation supports the existence of chronic tetanus and provides morphologic evidence for a peripheral action of tetanus toxin in humans.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalMuscle & Nerve
Issue number5
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Risk, W. S., Bosch, E. P., Kimura, J., Cancilla, P. A., Fischbeck, K. H., & Layzer, R. B. (1981). Chronic tetanus: Clinical report and histochemistry of muscle. Muscle & Nerve, 4(5), 363-366.