Chronic potassium loading in dogs. Effect of sodium intake on acid-base equilibrium

William E Haley, H. B. Garfinkel, J. R. Brunt, A. V. Williams

Research output: Contribution to journalArticle

Abstract

Chronic oral potassium (K) loading with subsequent alteration in sodium (Na) intake was accomplished in 12 normal dogs in order to investigate the influence of Na intake on acid-base equilibrium in the chronically K-loaded animal. Chronic K loading (20 mEq/kg/ day) for 7-21 days did not result in alteration in acid-base status as compared to control when adequate Na (2.5 mEq/kg/day) was ingested. Mild steady state metabolic acidosis occurred during Na restriction (10.1 ± 0.3 mEq/liter vs. 21.6 ± 0.3 mEq/liter HCO3, p < 0.001) associated with decreased K excretion (-18 ± 6 mEq/day, p < 0.01) and modest elevation of plasma K (4.4 ± 0.1 vs. 3.9 ± 0.1 mEq/liter, p < 0.01). Metabolic balance studies which were performed in 6 of the animals failed to reveal significant changes in net acid excretion to account for either the persistent acidosis occurring during Na restriction or the correction which occurred with return of dietary Na. These findings demonstrate that acid-base homeostasis may be maintained despite massive chronic K loading in the dog and suggest that this ability may be limited when Na intake is rigidly restricted.

Original languageEnglish (US)
Pages (from-to)302-311
Number of pages10
JournalMineral and Electrolyte Metabolism
Volume3
Issue number6
StatePublished - 1980
Externally publishedYes

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Acid-Base Equilibrium
Potassium
Sodium
Dogs
Acidosis
Acids
Animals
Homeostasis
Plasmas

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

Cite this

Chronic potassium loading in dogs. Effect of sodium intake on acid-base equilibrium. / Haley, William E; Garfinkel, H. B.; Brunt, J. R.; Williams, A. V.

In: Mineral and Electrolyte Metabolism, Vol. 3, No. 6, 1980, p. 302-311.

Research output: Contribution to journalArticle

Haley, William E ; Garfinkel, H. B. ; Brunt, J. R. ; Williams, A. V. / Chronic potassium loading in dogs. Effect of sodium intake on acid-base equilibrium. In: Mineral and Electrolyte Metabolism. 1980 ; Vol. 3, No. 6. pp. 302-311.
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