Chronic nitrofurantoin-induced lung disease

Jose L. Mendez, Hassan F. Nadrous, Thomas E. Hartman, Jay H Ryu

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

OBJECTIVE: To reassess the clinical and radiological features of chronic nitrofurantoin-induced lung disease and eventual clinical outcome. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 18 patients with chronic nitrofurantoin-induced lung disease who were seen at the Mayo Clinic in Rochester, Minn, from January 1, 1997, to December 31, 2002. RESULTS: The median age of the 13 patients was 72 years (range, 47-90 years) at the time of diagnosis; 17 (94%) were women. Onset of symptoms occurred after a median interval of 23 months (range, 10-144 months) following the initiation of nitrofurantoin therapy for the prevention of recurrent urinary tract infections. All patients presented with persistent dyspnea and cough associated with long infiltrates detected on chest radiography. Ten computed tomograms were available for review and revealed bilateral areas of ground-glass opacities in all cases and showed subpleural irregular linear opacities and patchy consolidation in some cases. Nitrofurantoin therapy was discontinued in all patients, and most improved subsequently; 9 patients received corticosteroid therapy. CONCLUSIONS: Chronic nitrofurantoin-induced lung disease is seen predominantly in older women who present with respiratory symptoms after a year or more of nitrofurantoin therapy. Associated radiological features are relatively nonspecific but usually include bilateral areas of ground-glass opacities on computed tomography of the chest. Cessation of nitrofurantoin therapy leads to improvement and suffices in the management of some patients, although corticosteroid therapy may be helpful in those more severely affected.

Original languageEnglish (US)
Pages (from-to)1298-1302
Number of pages5
JournalMayo Clinic Proceedings
Volume80
Issue number10
StatePublished - 2005

Fingerprint

Nitrofurantoin
Lung Diseases
Glass
Adrenal Cortex Hormones
Thorax
Therapeutics
Cough
Urinary Tract Infections
Radiography
Dyspnea
Medical Records
Tomography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mendez, J. L., Nadrous, H. F., Hartman, T. E., & Ryu, J. H. (2005). Chronic nitrofurantoin-induced lung disease. Mayo Clinic Proceedings, 80(10), 1298-1302.

Chronic nitrofurantoin-induced lung disease. / Mendez, Jose L.; Nadrous, Hassan F.; Hartman, Thomas E.; Ryu, Jay H.

In: Mayo Clinic Proceedings, Vol. 80, No. 10, 2005, p. 1298-1302.

Research output: Contribution to journalArticle

Mendez, JL, Nadrous, HF, Hartman, TE & Ryu, JH 2005, 'Chronic nitrofurantoin-induced lung disease', Mayo Clinic Proceedings, vol. 80, no. 10, pp. 1298-1302.
Mendez JL, Nadrous HF, Hartman TE, Ryu JH. Chronic nitrofurantoin-induced lung disease. Mayo Clinic Proceedings. 2005;80(10):1298-1302.
Mendez, Jose L. ; Nadrous, Hassan F. ; Hartman, Thomas E. ; Ryu, Jay H. / Chronic nitrofurantoin-induced lung disease. In: Mayo Clinic Proceedings. 2005 ; Vol. 80, No. 10. pp. 1298-1302.
@article{6e38cff427cd4a9ba6e7fbf69b8575c4,
title = "Chronic nitrofurantoin-induced lung disease",
abstract = "OBJECTIVE: To reassess the clinical and radiological features of chronic nitrofurantoin-induced lung disease and eventual clinical outcome. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 18 patients with chronic nitrofurantoin-induced lung disease who were seen at the Mayo Clinic in Rochester, Minn, from January 1, 1997, to December 31, 2002. RESULTS: The median age of the 13 patients was 72 years (range, 47-90 years) at the time of diagnosis; 17 (94{\%}) were women. Onset of symptoms occurred after a median interval of 23 months (range, 10-144 months) following the initiation of nitrofurantoin therapy for the prevention of recurrent urinary tract infections. All patients presented with persistent dyspnea and cough associated with long infiltrates detected on chest radiography. Ten computed tomograms were available for review and revealed bilateral areas of ground-glass opacities in all cases and showed subpleural irregular linear opacities and patchy consolidation in some cases. Nitrofurantoin therapy was discontinued in all patients, and most improved subsequently; 9 patients received corticosteroid therapy. CONCLUSIONS: Chronic nitrofurantoin-induced lung disease is seen predominantly in older women who present with respiratory symptoms after a year or more of nitrofurantoin therapy. Associated radiological features are relatively nonspecific but usually include bilateral areas of ground-glass opacities on computed tomography of the chest. Cessation of nitrofurantoin therapy leads to improvement and suffices in the management of some patients, although corticosteroid therapy may be helpful in those more severely affected.",
author = "Mendez, {Jose L.} and Nadrous, {Hassan F.} and Hartman, {Thomas E.} and Ryu, {Jay H}",
year = "2005",
language = "English (US)",
volume = "80",
pages = "1298--1302",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "10",

}

TY - JOUR

T1 - Chronic nitrofurantoin-induced lung disease

AU - Mendez, Jose L.

AU - Nadrous, Hassan F.

AU - Hartman, Thomas E.

AU - Ryu, Jay H

PY - 2005

Y1 - 2005

N2 - OBJECTIVE: To reassess the clinical and radiological features of chronic nitrofurantoin-induced lung disease and eventual clinical outcome. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 18 patients with chronic nitrofurantoin-induced lung disease who were seen at the Mayo Clinic in Rochester, Minn, from January 1, 1997, to December 31, 2002. RESULTS: The median age of the 13 patients was 72 years (range, 47-90 years) at the time of diagnosis; 17 (94%) were women. Onset of symptoms occurred after a median interval of 23 months (range, 10-144 months) following the initiation of nitrofurantoin therapy for the prevention of recurrent urinary tract infections. All patients presented with persistent dyspnea and cough associated with long infiltrates detected on chest radiography. Ten computed tomograms were available for review and revealed bilateral areas of ground-glass opacities in all cases and showed subpleural irregular linear opacities and patchy consolidation in some cases. Nitrofurantoin therapy was discontinued in all patients, and most improved subsequently; 9 patients received corticosteroid therapy. CONCLUSIONS: Chronic nitrofurantoin-induced lung disease is seen predominantly in older women who present with respiratory symptoms after a year or more of nitrofurantoin therapy. Associated radiological features are relatively nonspecific but usually include bilateral areas of ground-glass opacities on computed tomography of the chest. Cessation of nitrofurantoin therapy leads to improvement and suffices in the management of some patients, although corticosteroid therapy may be helpful in those more severely affected.

AB - OBJECTIVE: To reassess the clinical and radiological features of chronic nitrofurantoin-induced lung disease and eventual clinical outcome. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 18 patients with chronic nitrofurantoin-induced lung disease who were seen at the Mayo Clinic in Rochester, Minn, from January 1, 1997, to December 31, 2002. RESULTS: The median age of the 13 patients was 72 years (range, 47-90 years) at the time of diagnosis; 17 (94%) were women. Onset of symptoms occurred after a median interval of 23 months (range, 10-144 months) following the initiation of nitrofurantoin therapy for the prevention of recurrent urinary tract infections. All patients presented with persistent dyspnea and cough associated with long infiltrates detected on chest radiography. Ten computed tomograms were available for review and revealed bilateral areas of ground-glass opacities in all cases and showed subpleural irregular linear opacities and patchy consolidation in some cases. Nitrofurantoin therapy was discontinued in all patients, and most improved subsequently; 9 patients received corticosteroid therapy. CONCLUSIONS: Chronic nitrofurantoin-induced lung disease is seen predominantly in older women who present with respiratory symptoms after a year or more of nitrofurantoin therapy. Associated radiological features are relatively nonspecific but usually include bilateral areas of ground-glass opacities on computed tomography of the chest. Cessation of nitrofurantoin therapy leads to improvement and suffices in the management of some patients, although corticosteroid therapy may be helpful in those more severely affected.

UR - http://www.scopus.com/inward/record.url?scp=25844485965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844485965&partnerID=8YFLogxK

M3 - Article

C2 - 16212142

AN - SCOPUS:25844485965

VL - 80

SP - 1298

EP - 1302

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 10

ER -