Chronic myeloproliferative diseases with and without the Ph chromosome: Some unresolved issues

J. M. Goldman, A. R. Green, T. Holyoake, C. Jamieson, R. Mesa, T. Mughal, F. Pellicano, D. Perrotti, R. Skoda, A. M. Vannucchi

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Ph-positive chronic myeloid leukemia (CML) and Ph-negative chronic myeloproliferative diseases (MPDs), characterized in many cases by the presence of the JAK2V617F mutation, have many features in common and yet also show fundamental differences. In this review, we pose five discrete and related questions relevant to both categories of hematological malignancy, namely: What are the mechanisms that underlie disease progression from a relatively benign or chronic phase? By what therapeutic methods might one target residual leukemia stem cells in CML? Is JAK2V617F the original molecular event in MPD? What epigenetic events must have a role in dictating disease phenotype in MPDs? And finally, Will the benefits conferred by current or future JAK2V617F inhibitors equal or even surpass the clinical success that has resulted from the use of tyrosine kinase inhibitors in CML? These and others questions must be addressed and in some cases should be answered in the foreseeable future.

Original languageEnglish (US)
Pages (from-to)1708-1715
Number of pages8
JournalLeukemia
Volume23
Issue number10
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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