Chronic myelomonocytic leukemia and myelodysplastic syndrome/myeloproliferative overlap syndromes

Phuong L. Nguyen, Curtis A Hanson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Practicing hematologists and hematopathologists have long recognized that patients with myelodysplastic syndromes (MDS) typically present with cytopenia(s), and those with chronic myeloproliferative disorders (CMPD) typically present with elevated blood counts and organomegaly, but there are also patients who have clinical, laboratory, and/or pathologic features of both MDS and CMPD, and those patients are not easily assigned to either category. Thus, prior to the publication of the World Health Organization (WHO) classification of hematopoietic neoplasms (see chaps. 1 and 9), some patients with left-shifted neutrophilia and absolute monocytosis and morphologic features of dysgranulopoiesis were classified as chronic myelomonocytic leukemia (CMML) under the family of MDS, whereas others who also had left-shifted neutrophilia and morphologic features of dysgranulopoiesis but less monocytosis were classified as atypical chronic myeloid leukemia (aCML) under the CMPD umbrella.

Original languageEnglish (US)
Title of host publicationMyelodysplastic Syndromes
Subtitle of host publicationPathobiology and Clinical Management, Second Edition
PublisherCRC Press
Pages285-310
Number of pages26
ISBN (Electronic)9781420074406
ISBN (Print)1420074393, 9781420074390
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Nguyen, P. L., & Hanson, C. A. (2008). Chronic myelomonocytic leukemia and myelodysplastic syndrome/myeloproliferative overlap syndromes. In Myelodysplastic Syndromes: Pathobiology and Clinical Management, Second Edition (pp. 285-310). CRC Press.