TY - JOUR
T1 - Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features
AU - Huh, Yang O.
AU - Schweighofer, Carmen D.
AU - Ketterling, Rhett P.
AU - Knudson, Ryan A.
AU - Vega, Francisco
AU - Kim, Ji E.
AU - Luthra, Rajyalakshmi
AU - Keating, Michael J.
AU - Medeiros, L. Jeffrey
AU - Abruzzo, Lynne V.
PY - 2011/5
Y1 - 2011/5
N2 - The t(14;19)(q32;q13) involving the IGH@ and BCL3 loci is an infrequent cytogenetic abnormality detected in B-cell malignancies. We describe the clinicopathologic, cytogenetic, and molecular genetic characteristics of 14 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with t(14;19)(q32;q13). All patients (10 men and 4 women) had lymphocytosis; 10 had lymphadenopathy. Blood and bone marrow lymphocytes were predominantly small, but cytologically and immunophenotypically atypical. In all cases, t(14;19) was found in the neoplastic stem line; it was the sole abnormality in 4. Ten cases showed additional cytogenetic abnormalities, including trisomy 12 in 9 and complex karyotypes in 7. Fluorescence in situ hybridization demonstrated IGH@/BCL3 fusion gene in all cases. In all cases, the IGHV genes were unmutated, but only 7 expressed ZAP70. Seven cases preferentially used IGHV4-39. Our results indicate that t(14;19)(q32;q13) identifies a subset of CLL/SLL with distinctive clinicopathologic and genetic features. Furthermore, t(14;19) may represent an early, possibly primary, genetic event.
AB - The t(14;19)(q32;q13) involving the IGH@ and BCL3 loci is an infrequent cytogenetic abnormality detected in B-cell malignancies. We describe the clinicopathologic, cytogenetic, and molecular genetic characteristics of 14 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with t(14;19)(q32;q13). All patients (10 men and 4 women) had lymphocytosis; 10 had lymphadenopathy. Blood and bone marrow lymphocytes were predominantly small, but cytologically and immunophenotypically atypical. In all cases, t(14;19) was found in the neoplastic stem line; it was the sole abnormality in 4. Ten cases showed additional cytogenetic abnormalities, including trisomy 12 in 9 and complex karyotypes in 7. Fluorescence in situ hybridization demonstrated IGH@/BCL3 fusion gene in all cases. In all cases, the IGHV genes were unmutated, but only 7 expressed ZAP70. Seven cases preferentially used IGHV4-39. Our results indicate that t(14;19)(q32;q13) identifies a subset of CLL/SLL with distinctive clinicopathologic and genetic features. Furthermore, t(14;19) may represent an early, possibly primary, genetic event.
KW - Atypical morphology
KW - BCL3
KW - Chronic lymphocytic leukemia
KW - IGHV somatic mutation
KW - t(14;19)(q32;q13)
UR - http://www.scopus.com/inward/record.url?scp=79955046604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955046604&partnerID=8YFLogxK
U2 - 10.1309/AJCPOEFP3SLX6HXJ
DO - 10.1309/AJCPOEFP3SLX6HXJ
M3 - Article
C2 - 21502423
AN - SCOPUS:79955046604
SN - 0002-9173
VL - 135
SP - 686
EP - 696
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 5
ER -