Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder: Response to chemotherapy in two cases

Leo I. Gordon, William Hrushesky, Martin M. Oken, Neil E. Kay, Robert E. Rydell

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalMedical and Pediatric Oncology
Volume7
Issue number2
DOIs
StatePublished - 1979

Keywords

  • Richters syndrome
  • leukemia
  • lymphoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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