Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder: Response to chemotherapy in two cases

L. I. Gordon, W. Hrushesky, M. M. Oken, Neil Elliot Kay, R. E. Rydell

Research output: Contribution to journalArticle

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Abstract

The development of either histiocytic lymphoma or Hodgkin disease in association with pre-existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalMedical and Pediatric Oncology
Volume7
Issue number2
DOIs
StatePublished - 1979
Externally publishedYes

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Lymphoproliferative Disorders
B-Cell Chronic Lymphocytic Leukemia
Drug Therapy
Lymphoma, Large B-Cell, Diffuse
Drug Combinations
Hodgkin Disease
Lymphoma
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder : Response to chemotherapy in two cases. / Gordon, L. I.; Hrushesky, W.; Oken, M. M.; Kay, Neil Elliot; Rydell, R. E.

In: Medical and Pediatric Oncology, Vol. 7, No. 2, 1979, p. 111-116.

Research output: Contribution to journalArticle

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