Abstract
The development of either histiocytic lymphoma or Hodgkin disease in association with pre‐existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.
Original language | English (US) |
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Pages (from-to) | 111-116 |
Number of pages | 6 |
Journal | Medical and Pediatric Oncology |
Volume | 7 |
Issue number | 2 |
DOIs | |
State | Published - 1979 |
Keywords
- Richters syndrome
- leukemia
- lymphoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Cancer Research