Chronic inflammatory polyradiculoneuropathy

Peter J Dyck, A. C. Lais, M. Ohta, J. A. Bastron, H. Okazaki, R. V. Groover

Research output: Contribution to journalArticle

626 Citations (Scopus)

Abstract

The diagnostic criteria, natural history, nerve conduction characteristics, pathology, laboratory features, and efficacy of corticosteroid treatment have been evaluated personally in 53 patients with chronic inflammatory polyradiculoneuropathy (CIP) who were followed up for an average of about 7.5 years. These were patients whose monophasic neurologic deficit had not crested by 6 months, patients with recurrences, and patients with a steady or stepwise progression. The typical features of CIP include absence of an associated disease, frequent history of preceding infection or receipt of foreign protein, and tendency to involve cranial, truncal, and proximal as well as distal limb structures and to have diffusely slow conduction velocity of peripheral nerves. The most marked slowing is very often proximal. The pathologic features include serous edema, mononuclear cell infiltrates (especially in perivascular areas, but without evidence of vasculitis), macrophage induced segmental demyelination and hypertrophic neuritis. If our patients are representative, complete recovery occurs only infrequently; about 60% of patients are able to be ambulatory and work, 25% become confined to a wheelchair or become bedridden, and approximately 10% die from their disease. Although the bulk of the pathologic changes affect spinal roots and proximal nerves, the brain and spinal cord may be involved also. Degeneration into linear rows of myelin ovoids is the predominant type of myelinated fiber degeneration of the sural nerve at the ankle.

Original languageEnglish (US)
Pages (from-to)621-637
Number of pages17
JournalMayo Clinic Proceedings
Volume50
Issue number11
StatePublished - 1975

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Patient Advocacy
Neuritis
Sural Nerve
Wheelchairs
Spinal Nerve Roots
Neural Conduction
Demyelinating Diseases
Myelin Sheath
Vasculitis
Neurologic Manifestations
Natural History
Peripheral Nerves
Ankle
Edema
Spinal Cord
Adrenal Cortex Hormones
Extremities
Macrophages
Pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dyck, P. J., Lais, A. C., Ohta, M., Bastron, J. A., Okazaki, H., & Groover, R. V. (1975). Chronic inflammatory polyradiculoneuropathy. Mayo Clinic Proceedings, 50(11), 621-637.

Chronic inflammatory polyradiculoneuropathy. / Dyck, Peter J; Lais, A. C.; Ohta, M.; Bastron, J. A.; Okazaki, H.; Groover, R. V.

In: Mayo Clinic Proceedings, Vol. 50, No. 11, 1975, p. 621-637.

Research output: Contribution to journalArticle

Dyck, PJ, Lais, AC, Ohta, M, Bastron, JA, Okazaki, H & Groover, RV 1975, 'Chronic inflammatory polyradiculoneuropathy', Mayo Clinic Proceedings, vol. 50, no. 11, pp. 621-637.
Dyck PJ, Lais AC, Ohta M, Bastron JA, Okazaki H, Groover RV. Chronic inflammatory polyradiculoneuropathy. Mayo Clinic Proceedings. 1975;50(11):621-637.
Dyck, Peter J ; Lais, A. C. ; Ohta, M. ; Bastron, J. A. ; Okazaki, H. ; Groover, R. V. / Chronic inflammatory polyradiculoneuropathy. In: Mayo Clinic Proceedings. 1975 ; Vol. 50, No. 11. pp. 621-637.
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