Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease

Richard John Caselli, B. W. Scheithauer, J. D. O'Duffy, G. C. Peterson, B. F. Westmoreland, P. A. Davenport

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


We describe two patients with a chronic encephalopathy that clinically resembled dementia but that resolved after oral administration of high-dose corticosteroid therapy. Both patients had serologically documented Sjogren's syndrome, a diagnosis that was further supported by biopsy of a salivary gland in one. Neither patient had radiologic evidence of vasculitis of the central nervous system. In one patient, meningeal and brain biopsy specimens showed perivascular inflammatory lymphocytic infiltrates. Chronic inflammatory meningoencephalitis is a treatable cause of chronic encephalopathy that should be clinically distinguished from dementia associated with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalMayo Clinic Proceedings
Issue number9
StatePublished - 1993

ASJC Scopus subject areas

  • Medicine(all)


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