Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease

Richard John Caselli, B. W. Scheithauer, J. D. O'Duffy, G. C. Peterson, B. F. Westmoreland, P. A. Davenport

Research output: Contribution to journalArticle

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Abstract

We describe two patients with a chronic encephalopathy that clinically resembled dementia but that resolved after oral administration of high-dose corticosteroid therapy. Both patients had serologically documented Sjogren's syndrome, a diagnosis that was further supported by biopsy of a salivary gland in one. Neither patient had radiologic evidence of vasculitis of the central nervous system. In one patient, meningeal and brain biopsy specimens showed perivascular inflammatory lymphocytic infiltrates. Chronic inflammatory meningoencephalitis is a treatable cause of chronic encephalopathy that should be clinically distinguished from dementia associated with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalMayo Clinic Proceedings
Volume68
Issue number9
StatePublished - 1993

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Meningoencephalitis
Alzheimer Disease
Chronic Brain Damage
Dementia
Central Nervous System Vasculitis
Biopsy
Sjogren's Syndrome
Salivary Glands
Oral Administration
Adrenal Cortex Hormones
Brain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Caselli, R. J., Scheithauer, B. W., O'Duffy, J. D., Peterson, G. C., Westmoreland, B. F., & Davenport, P. A. (1993). Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease. Mayo Clinic Proceedings, 68(9), 846-853.

Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease. / Caselli, Richard John; Scheithauer, B. W.; O'Duffy, J. D.; Peterson, G. C.; Westmoreland, B. F.; Davenport, P. A.

In: Mayo Clinic Proceedings, Vol. 68, No. 9, 1993, p. 846-853.

Research output: Contribution to journalArticle

Caselli, RJ, Scheithauer, BW, O'Duffy, JD, Peterson, GC, Westmoreland, BF & Davenport, PA 1993, 'Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease', Mayo Clinic Proceedings, vol. 68, no. 9, pp. 846-853.
Caselli RJ, Scheithauer BW, O'Duffy JD, Peterson GC, Westmoreland BF, Davenport PA. Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease. Mayo Clinic Proceedings. 1993;68(9):846-853.
Caselli, Richard John ; Scheithauer, B. W. ; O'Duffy, J. D. ; Peterson, G. C. ; Westmoreland, B. F. ; Davenport, P. A. / Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease. In: Mayo Clinic Proceedings. 1993 ; Vol. 68, No. 9. pp. 846-853.
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