TY - JOUR
T1 - Chronic Inflammatory Meningoencephalitis Should Not Be Mistaken for Alzheimer's Disease
AU - CASELLI, RICHARD J.
AU - SCHEITHAUER, BERND W.
AU - O'DUFFY, J. DESMOND
AU - PETERSON, GERALD C.
AU - WESTMORELAND, BARBARA F.
AU - DAVENPORT, PHILIP A.
PY - 1993
Y1 - 1993
N2 - We describe two patients with a chronic encephalopathy that clinically resembled dementia but that resolved after oral administration of high-dose corticosteroid therapy. Both patients had serologically documented Sjögren's syndrome, a diagnosis that was further supported by biopsy of a salivary gland in one. Neither patient had radiologic evidence of vasculitis of the central nervous system. In one patient, meningeal and brain biopsy specimens showed perivascular inflammatory lymphocytic infiltrates. Chronic inflammatory meningoencephalitis is a treatable cause of chronic encephalopathy that should be clinically distinguished from dementia associated with Alzheimer's disease.
AB - We describe two patients with a chronic encephalopathy that clinically resembled dementia but that resolved after oral administration of high-dose corticosteroid therapy. Both patients had serologically documented Sjögren's syndrome, a diagnosis that was further supported by biopsy of a salivary gland in one. Neither patient had radiologic evidence of vasculitis of the central nervous system. In one patient, meningeal and brain biopsy specimens showed perivascular inflammatory lymphocytic infiltrates. Chronic inflammatory meningoencephalitis is a treatable cause of chronic encephalopathy that should be clinically distinguished from dementia associated with Alzheimer's disease.
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U2 - 10.1016/S0025-6196(12)60692-2
DO - 10.1016/S0025-6196(12)60692-2
M3 - Article
C2 - 8371602
AN - SCOPUS:0027284055
SN - 0025-6196
VL - 68
SP - 846
EP - 853
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 9
ER -